AKAP10 Antibody

說明書

中文名稱：

AKAP10兔多克隆抗體
貨號：

CSB-PA250245
規格：

￥2024
圖片：
Western blot analysis of extracts from mouse brain cells, using AKAP10 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AKAP10 Polyclonal antibody
Uniprot No.：

O43572
基因名：

AKAP10
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from Internal of Human AKAP10.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
基因功能參考文獻：
1. Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. PMID: 28553927
2. Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed. PMID: 26110499
3. Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms. PMID: 25213315
4. Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1. PMID: 25348485
5. Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer. PMID: 23468363
6. Questioned whether 1936A>G is associated with metabolic changes in newborns that are predictive of the metabolic phenotype in adults. Demonstrate an association between 1936G variant and total cholesterol level in cord blood of Polish newborns. PMID: 23095189
7. There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns. PMID: 22817328
8. No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender. PMID: 23092224
9. Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults. PMID: 21701445
10. Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2. PMID: 20159461
11. AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation. PMID: 19857670
12. There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer. PMID: 19462906
13. deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein PMID: 12206784
14. A variant of the kinase-binding domain of this enzyme involves a disease susceptibility polymorphism. PMID: 12646697
15. Results describe the structural features of dual-specificity A kinase-anchoring protein 2 (D-AKAP2) and its interaction with protein kinase A (PKA). PMID: 15488188
16. These studies suggest a role for AKAP10 in heart rhythm control. PMID: 17485678
17. AKAP10 2073A>G variation is associated with an increased risk of colorectal cancer in the Chinese population. PMID: 19209010
18. the AKAP10 Val allele predicted greater resting heart rate and heart rate variability PMID: 19496216
19. D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment PMID: 19797056
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相關疾病：

Sudden cardiac death (SCD)
亞細胞定位：

Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
數據庫鏈接：

HGNC: 368

OMIM: 115080

KEGG: hsa:11216

STRING: 9606.ENSP00000225737

UniGene: Hs.642676

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