DLL3
DLL3，即Delta樣配體3，別名Delta3、delta-like3(Drosophila)、delta-likeprotein3、Pudgy、SCDO1、SCDO1delta3。它是一種屬于Delta/Serrate/Lag-2(DSL)家族的Notch配體，主要在神經(jīng)內(nèi)分泌腫瘤細(xì)胞表面表達(dá)，而在正常成人組織中幾乎不表達(dá)。DLL3的作用機(jī)制涉及與Notch受體相互作用，通常作為抑制性配體，通過(guò)與Notch受體結(jié)合抑制Notch信號(hào)通路的激活，影響腫瘤細(xì)胞的增殖、分化和凋亡。DLL3在小細(xì)胞肺癌（SCLC）中的表達(dá)尤為重要，其高表達(dá)與腫瘤的發(fā)生發(fā)展密切相關(guān)，是治療SCLC的潛在藥物作用靶點(diǎn)。DLL3的異常表達(dá)與多種神經(jīng)內(nèi)分泌腫瘤的發(fā)生有關(guān)，使其成為小細(xì)胞肺癌治療的重要生物標(biāo)志物和治療靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human Delta-like protein 3 (DLL3), partial (CSB-EP882142HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DLL3 Recombinant Monoclonal Antibody (CSB-RA882142A1HU)
驗(yàn)證數(shù)據(jù)
Untransfected HEK293 cells surface (green line) and transfected Human DLL3 HEK293 stable cells surface (red line) were stained with anti-DLL3 antibody (rovalpituzumab-like) (2μl/1*106 cells), washed and then followed by FITC-conjugated anti-Human IgG1 Fc antibody and analyzed with flow cytometry.
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP3536MOV) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.625-2.702 ng/mL.
The Binding Activity of DLL3 with Anti-DLL3 Recombinant Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized DLL3 (CSB-MP882142HU) at 2 μg/mL can bind Anti-DLL3 Recombinant Antibody(CSB-RA882142A1HU), the EC50 is 1.102-1.707 ng/mL.
The purity of DLL3 was greater than 95% as determined by SEC-HPLC
Human Delta-like protein 3(DLL3) ELISA kit (CSB-EL006948HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL006948HU
規(guī)格：96T/48T
靈敏度：4.68 pg/mL
檢測(cè)范圍：18.75 pg/mL-1200 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
DLL3 Antibodies
DLL3 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA882142LA01HU | DLL3 Antibody | Human | ELISA, IHC |
| CSB-PA882142LB01HU | DLL3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA882142LC01HU | DLL3 Antibody, FITC conjugated | Human | |
| CSB-PA882142LD01HU | DLL3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA882142A1HU | DLL3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
| CSB-RA882142MA2HU | DLL3 Recombinant Monoclonal Antibody | Human | ELISA, FC |
DLL3 Proteins
DLL3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006948MO1 CSB-EP006948MO1 CSB-BP006948MO1 CSB-MP006948MO1 CSB-EP006948MO1-B |
Recombinant Mouse Delta-like protein 3 (Dll3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006948MO | Recombinant Mouse Delta-like protein 3 (Dll3) | in vitro E.coli expression system |
DLL3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006948RA1 CSB-EP006948RA1 CSB-BP006948RA1 CSB-MP006948RA1 CSB-EP006948RA1-B |
Recombinant Rat Delta-like protein 3 (Dll3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006948RA | Recombinant Rat Delta-like protein 3 (Dll3) | in vitro E.coli expression system |
DLL3 Proteins for Xenopus laevis (African clawed frog)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP346574XBE CSB-EP346574XBE CSB-BP346574XBE CSB-MP346574XBE CSB-EP346574XBE-B |
Recombinant Xenopus laevis Homeobox protein DLL-3 (dll3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DLL3 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial | Yeast |
| CSB-EP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial | E.coli |
| CSB-EP882142HU1 | Recombinant Human Delta-like protein 3 (DLL3), partial | E.coli |
| CSB-MP882142HU | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
| CSB-EP882142HU2-B | Recombinant Human Delta-like protein 3 (DLL3), partial,Biotinylated | E.coli |
| CSB-MP882142HU2 | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
| CSB-MP882142HU2d7 | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
| CSB-MP882142HU3 | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
| CSB-MP882142HU3d7 | Recombinant Human Delta-like protein 3 (DLL3), partial (Active) | Mammalian cell |
DLL3 ELISA Kit
DLL3 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006948HU | Human Delta-like protein 3(DLL3) ELISA kit | serum, plasma, tissue homogenates | 4.68 pg/mL |
