TM4SF1
TM4SF1（Transmembrane 4 L six family member 1）是Tetraspanin超家族中亞家族TM4SFs的一員，首次于1986年被鑒定。它具有Tetraspanin家族典型的四次跨膜結(jié)構(gòu)，胞外含兩個loop區(qū)EC1和EC2，其中EC2區(qū)可通過半胱氨酸殘基與整合素α5β1結(jié)合，影響細(xì)胞的黏附和運(yùn)動。C端胞質(zhì)區(qū)包含PDZ結(jié)合域，可與Syntenin-1和Syntenin-2蛋白相互作用介導(dǎo)腫瘤細(xì)胞的增殖和轉(zhuǎn)移。 TM4SF1在多種腫瘤細(xì)胞表面高表達(dá)，包括肺癌、乳腺癌、肝癌、結(jié)直腸癌及卵巢癌等，且能與脂質(zhì)激酶、酪氨酸蛋白激酶等形成復(fù)合體，如可結(jié)合DDR1，激活PKC和JAK2-STAT3信號通路，促進(jìn)細(xì)胞偽足延伸。初步的研究結(jié)果表明，TM4SF1作為具有酪氨酸蛋白激酶活性的單次跨膜受體1（DDR1）的輔助受體，調(diào)控下游的PKC/STAT3信號通路，從而影響乳腺癌向肺組織的轉(zhuǎn)移。此外，TM4SF1也是具有新型內(nèi)化途徑的ADC靶點(diǎn)，這意味著它在抗體偶聯(lián)藥物（ADC）的設(shè)計(jì)和開發(fā)中可能具有潛在的應(yīng)用價值。 于TM4SF1的藥物研發(fā)處于初級階段，尚未有成熟的藥物應(yīng)用于臨床治療。因此，對于TM4SF1的研究仍具有深遠(yuǎn)的意義和廣闊的前景。
熱銷產(chǎn)品
● Recombinant Human Transmembrane 4 L6 family member 1(TM4SF1)-VLPs (Active)
驗(yàn)證數(shù)據(jù)
CSB-MP023615HU is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU)， the EC50 is 4.079-4.472 ng/mL.VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC.
● Recombinant Macaca fascicularis Transmembrane 4 L6 family member 1 (TM4SF1)-VLPs (Active)
驗(yàn)證數(shù)據(jù)
CSB-MP5031MOV is detected by Mouse anti-6*His monoclonal antibody.The two bands respectively correspond to monomer, Homodimer.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus TM4SF1 at 5μg/mL can bind Anti-TM4SF1 recombinant antibody(CSB-RA023615MA1HU)， the EC50 is 4.480-4.930 ng/mL.VLPs (CSB-MP3838) is negative control.
The purity of VLPs was greater than 95% as determined by SEC-HPLC
TM4SF1 Antibodies
TM4SF1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA009895 | TM4SF1 Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA982780 | TM4SF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA017058 | TM4SF1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA023615LA01HU | TM4SF1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA023615LD01HU | TM4SF1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA023615LC01HU | TM4SF1 Antibody, FITC conjugated | Human | |
| CSB-PA023615LB01HU | TM4SF1 Antibody, HRP conjugated | Human | ELISA |
| CSB-RA023615MA1HU | TM4SF1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
TM4SF1 Proteins
TM4SF1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023615HU CSB-EP023615HU CSB-BP023615HU CSB-EP023615HU-B |
Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-CF023615HU | Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1) | in vitro E.coli expression system |
| CSB-YP023615HU1 | Recombinant Human Transmembrane 4 L6 family member 1 (TM4SF1), partial | Yeast |
| CSB-MP023615HU | Recombinant Human Transmembrane 4 L6 family member 1(TM4SF1)-VLPs (Active) | Mammalian cell |
