AKAP10 Antibody
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中文名稱(chēng)：AKAP10兔多克隆抗體
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貨號(hào)：CSB-PA001519ESR1HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: AKAP10 antibody at 7μg/ml
Lane 1: 293T whole cell lysate
Lane 2: Hela whole cell lysate
Lane 3: HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 74 kDa
Observed band size: 74 kDa -
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA001519ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA001519ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱(chēng)：Rabbit anti-Homo sapiens (Human) AKAP10 Polyclonal antibody
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Uniprot No.：
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基因名：AKAP10
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別名：AKAP10A-kinase anchor protein 10 antibody; mitochondrial antibody; AKAP-10 antibody; Dual specificity A kinase-anchoring protein 2 antibody; D-AKAP-2 antibody; Protein kinase A-anchoring protein 10 antibody; PRKA10 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human A-kinase anchor protein 10, mitochondrial protein (413-662AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類(lèi)型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:1000 IHC 1:20-1:200 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
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基因功能參考文獻(xiàn)：
- Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. PMID: 28553927
- Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed. PMID: 26110499
- Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms. PMID: 25213315
- Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1. PMID: 25348485
- Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer. PMID: 23468363
- Questioned whether 1936A>G is associated with metabolic changes in newborns that are predictive of the metabolic phenotype in adults. Demonstrate an association between 1936G variant and total cholesterol level in cord blood of Polish newborns. PMID: 23095189
- There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns. PMID: 22817328
- No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender. PMID: 23092224
- Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults. PMID: 21701445
- Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2. PMID: 20159461
- AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation. PMID: 19857670
- There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer. PMID: 19462906
- deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein PMID: 12206784
- A variant of the kinase-binding domain of this enzyme involves a disease susceptibility polymorphism. PMID: 12646697
- Results describe the structural features of dual-specificity A kinase-anchoring protein 2 (D-AKAP2) and its interaction with protein kinase A (PKA). PMID: 15488188
- These studies suggest a role for AKAP10 in heart rhythm control. PMID: 17485678
- AKAP10 2073A>G variation is associated with an increased risk of colorectal cancer in the Chinese population. PMID: 19209010
- the AKAP10 Val allele predicted greater resting heart rate and heart rate variability PMID: 19496216
- D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment PMID: 19797056
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相關(guān)疾病：Sudden cardiac death (SCD)
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亞細(xì)胞定位：Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.
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