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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase.
基因功能參考文獻(xiàn):
Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO) signaling, together with the GATA1 transcriptional target, AKAP10, regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane. PMID: 28553927
Significant association between the AKAP10 polymorphisms and reduced risk of Preterm birth in the Malays was observed. PMID: 26110499
Its signaling pathway is associated with the progression and prognosis of colorectal neoplasms. PMID: 25213315
Described is a structure of D-AKAP2 in complex with two interacting partners and the exact mechanism by which a segment that on its own is disordered presents an alpha-helix to PKA and a beta-strand to PDZK1. PMID: 25348485
Studied the clinicopathologic significance of A-kinase anchoring proteins 10 (AKAP 10) expression and the relationship with its polymorphism in colorectal cancer. PMID: 23468363
Questioned whether 1936A>G is associated with metabolic changes in newborns that are predictive of the metabolic phenotype in adults. Demonstrate an association between 1936G variant and total cholesterol level in cord blood of Polish newborns. PMID: 23095189
There is possible association between a 1936G AKAP10 variant and blood pressure in Polish newborns. PMID: 22817328
No significant differences were found in AKAP10 genotype or allele distribution between the age groups (newborn vs. nonagenerian) for either gender. PMID: 23092224
Results suggest G1936 polymorphism in A-kinase-anchoring protein is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults. PMID: 21701445
Results describe the structures of the protein kinase A RIalpha subunit D/D domain alone and in complex with D-AKAP2. PMID: 20159461
AKAP10 single nucleotide polymorphism is associated with increased risk of arrhythmia during kidney transplantation. PMID: 19857670
There was a significant association between AKAP10 gene 2073A/G polymorphism and colorectal cancer. PMID: 19462906
deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein PMID: 12206784
A variant of the kinase-binding domain of this enzyme involves a disease susceptibility polymorphism. PMID: 12646697
Results describe the structural features of dual-specificity A kinase-anchoring protein 2 (D-AKAP2) and its interaction with protein kinase A (PKA). PMID: 15488188
These studies suggest a role for AKAP10 in heart rhythm control. PMID: 17485678
AKAP10 2073A>G variation is associated with an increased risk of colorectal cancer in the Chinese population. PMID: 19209010
the AKAP10 Val allele predicted greater resting heart rate and heart rate variability PMID: 19496216
D-AKAP2 promotes accumulation of recycling proteins in the Rab4/Rab11-positive endocytic recycling compartment PMID: 19797056
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相關(guān)疾病:
Sudden cardiac death (SCD)
亞細(xì)胞定位:
Mitochondrion. Membrane. Cytoplasm. Note=Predominantly mitochondrial but also membrane associated and cytoplasmic.