VDR Recombinant Monoclonal Antibody

說明書

中文名稱：

VDR重組抗體
貨號：

CSB-RA945260A0HU
規格：

￥1320
圖片：
Western Blot
Positive WB detected in: MCF-7 whole cell lysate, THP-1 whole cell lysate, HL-60 whole cell lysate
All lanes: Vitamin D antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 49, 54 kDa
Observed band size: 49 kDa

IHC image of CSB-RA945260A0HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA945260A0HU VDR重組單克隆抗體是針對維生素D受體（Vitamin D Receptor）研發的高特異性檢測工具。該抗體經多種實驗驗證，在Western Blot中可呈現清晰單一的目標條帶，推薦使用稀釋度為1:500-1:5000；在免疫組化實驗中能精準顯示組織樣本中VDR蛋白的核定位特征，建議工作濃度為1:50-1:200。VDR作為核受體超家族成員，在鈣磷代謝調控、細胞分化及免疫應答中發揮關鍵作用，其異常表達與骨質疏松、腫瘤發生及自身免疫疾病密切相關。本產品適用于探究維生素D信號通路機制、疾病模型中受體表達水平變化以及相關分子調控網絡研究，可為代謝性疾病、腫瘤生物學及免疫調節領域的體外實驗提供可靠支持，滿足細胞實驗、組織樣本分析等科研需求。
Uniprot No.：

P11473
基因名：

VDR
別名：

Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1), VDR, NR1I1
反應種屬：

Human
免疫原：

A synthesized peptide derived from human Vitamin D Receptor
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

3C7
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis.
基因功能參考文獻：
1. Vitamin D Receptor Gene SNPs and the environment interact to Influence survival in hemodialysis patients. PMID: 30087217
2. Results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of premature birth. PMID: 30150529
3. SNPs of the VDR and GC genes are associated with vitamin D deficiency in postmenopausal Mexican women. PMID: 30150596
4. VDR gene FokI polymorphism is associated with papillary thyroid cancer. PMID: 30486759
5. No significant associations were found between the VDR polymorphisms analysed and Developmental dysplasia of the hip . Further work need to be performed using genomewide analysis to elucidate the genetic basis of Developmental dysplasia of the hip . PMID: 30262704
6. There was no significant association detected between BMI and rs1544410 of VDR in the Emirati population PMID: 29343214
7. Apparently, VDR-mediated signaling pathways seem to be dysregulated in those pathological conditions PMID: 30096760
8. Vitamin D Receptorgene TaqI and BsmI polymorphisms might contribute to the increased risk of hallux valgus in Chinese population. Apal or Fokl polymorphisms showed no increased susceptibility. PMID: 29705233
9. PTPN2, an anti-inflammatory factor regulated by VDR, was reduced in type 2 diabetics with chronic kidney disease stages 1-2. PMID: 30246029
10. ApaI gene polymorphism and Fok1 FF genotype were associated with renal cell carcinoma susceptibility in Asians PMID: 29970659
11. findings show polymorphism Taq-1 occurring in the vitamin D receptor may have an impact on the development of acute pancreatitis due to the lack of the protective role of vitamin D. PMID: 29966312
12. only VDR FokI polymorphism is associated with Hashimoto's thyroiditis risk in Asian population, but not in Caucasians; and the TaqI, ApaI and BsmI polymorphisms have not positive association neither in the overall population (Meta-Analysis) PMID: 28134349
13. Loss of function VDR mutation is associated with Hereditary 1,25-dihydroxyvitamin D-resistant rickets. PMID: 29949513
14. JNK1 and VDR act as tumor suppressors, and their stromal expression levels are associated with prognosis in esophageal squamous cell carcinoma. PMID: 29423673
15. Associations between VDR gene polymorphisms and osteoporosis risk and bone mineral density in postmenopausal women have been documented. (Meta-analysis) PMID: 29343720
16. Vitamin D deficiency and vitamin D receptor variants in mothers and their neonates are risk factors for neonatal sepsis PMID: 29530503
17. Study identified that CCC and TCC VDR haplotypes are risk factors for diabetic nephropathy in patients with diabetes type 2. PMID: 30315926
18. The VDR rs2228570 variant may increase susceptibility to dyslipidemia in the Chinese Han population. PMID: 30119682
19. NB-UVB phototherapy is associated with improved cutaneous VDR expression and vitamin D synthesis. Better repigmentation response to NB-UVB may be related to higher baseline VDR expression and its upregulation after phototherapy PMID: 29080365
20. Vitamin D Receptor Gene Polymorphism is associated with Breast Cancer. PMID: 28780723
21. Studied association of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) and promoter region deletions of toll like receptor 2 (TLR2) with genetic predisposition for pulmonary tuberculosis (PTB) in India communities. Results show that the BsmI and FokI polymorphisms of the VDR gene are significantly associated with an increased risk of PTB. PMID: 29727015
22. Results disclose FokI polymorphism as a relevant variant capturing the association of VDR polymorphisms with viral infection. PMID: 30092343
23. VDR (rs1544410) SNP was found to be associated with decreased serum (25[OH]D) levels. PMID: 29738868
24. CA genotype of ApaI VDR gene polymorphism was associated with family history and C allele of ApaI was related with family history and hypercalciuria in under one-year-old infants from Turkey. PMID: 29085969
25. A total of six Bcell epitopes and three Tcell epitopes for VDR were predicted by bioinformatics, which when validated, may in the future aid in immunological diagnosis and development of a targeted drug therapy for clinical asthma. PMID: 29901144
26. Review/Meta-analysis: VDR Tru9I polymorphism may be associated with osteoporosis risk in Chinese individuals, but BsmI, ApaI polymorphisms might not be a risk factor for osteoporosis. PMID: 29624920
27. Our data reveal that VDR plays a central role in protecting cells from excessive respiration and production of ROS that leads to cell damage. PMID: 29874855
28. This study emphasizes a positive association between SNPs (Fok-I and Bsm-I) and T1DM among Saudi children with increased risk with the Fok-I F and Bsm-I b alleles. PMID: 29417618
29. The Apa-I variant in VDR gene is associated with metabolic syndrome in southern Brazilian women with polycystic ovary syndrome. PMID: 29669566
30. Whole blood VDR gene expression was significantly higher in the autistic disorder group compared to control subjects (p < 0.0001). There were no significant differences among allele and genotype distribution of rs11568820 and rs4516035 polymorphisms between autistic disorder patients and controls. PMID: 29777458
31. Vitamin D receptor ApaI AC genotype may be a possible cardiovascular risk factor for the development of arteriovenous fistula failure. PMID: 29544394
32. preliminary results indicate the VDR gene ApaI, BsmI, FokI, and TaqI polymorphisms may not be associated with elevated multiple sclerosis (MS) risk among overall populations, but ApaI polymorphism may confer different susceptibility to MS among different populations - systematic review and meta-analysis PMID: 29110148
33. Studied association between 25-hydroxy vitamin D (25[OH]D) levels and vitamin D receptor (VDR) gene polymorphism in association with diabetes type 2. PMID: 28739347
34. The VDR Tru9I 'uu' genotype may increase the risk of premenopausal breast cancer. PMID: 29529900
35. Low VDR expression is associated with Coronary Artery Disease. PMID: 29176261
36. Expression analyses showed significant downregulation of VDR expression in peripheral blood of epileptic patients compared with healthy subjects. PMID: 29549592
37. This meta-analysis demonstrated the association between FokI and ApaI polymorphisms in VDR gene with the risk of BD, providing insights into the potential role of vitamin D receptor in the pathogenesis of BD. PMID: 29388852
38. Vitamin D receptor polymorphisms is a risk factor for multiple sclerosis susceptibility and progression in the Czech population. PMID: 29589202
39. important role for SOST SNP rs1877632 and VDR SNPs rs10735810 and rs731236 in the pathophysiology of stress fracture PMID: 29129460
40. CT genotype and the C allele of VDR were significantly associated with increased risks of childhood autism spectrum disorder. PMID: 29581796
41. Study found a significant association between multiple sclerosis and the VDR FokI polymorphism in our region of Turkey. PMID: 29331875
42. VDR's Fok-I and Taq-I show significant association with risk of RRMS, while Apa-I and Bsm-I are not related to the risk of the disease in Iranian Kurds. PMID: 29072967
43. The VDR rs2228570 polymorphism increases the risk of ovarian cancer in Caucasian populations in a dominant genetic model. PMID: 29239065
44. The present study indicates an association between VDR and vitamin D binding protein Single Nucleotide Polymorphisms and Type 1 Diabetes Mellitus among Turkish subjects. PMID: 29506625
45. Review/Meta-analysis: VDR B allele, and BB + Bb genotypes of Bsm I variant, Tt genotype of Taq I variant might be risk factors for diabetic nephropathy. PMID: 28703918
46. The VDR Bb genotype is an independent predictor of developing secondary hyperparathyroidism in patients with end stage kidney disease. PMID: 29415666
47. FokI and TaqI VDR variants are significantly associated with systemic lupus erythematosus in an eastern Indian cohort. PMID: 29230954
48. examination of the evidence for the role of Vitamin D Receptor (VDR) Polymorphisms in autoimmune diseases (review). PMID: 28786260
49. results suggests that there may be a relationship between certain VDR genotype combinations and the risk of preterm birth. PMID: 27958635
50. VDR BsmI polymorphism was associated with decreased risk of periodontitis in Chinese individuals from South China (meta-analysis). PMID: 29208185
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相關疾病：

Rickets vitamin D-dependent 2A (VDDR2A)
亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Nuclear hormone receptor family, NR1 subfamily
數據庫鏈接：

HGNC: 12679

OMIM: 277440

KEGG: hsa:7421

STRING: 9606.ENSP00000447173

UniGene: Hs.524368

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