Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

1. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches. PMID: 25320278
2. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT and could potentially serve as an anti-inflammatory drug inhibiting GALT-specific lymphocyte migration PMID: 21430257
3. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis PMID: 21341265
4. Observed a significant decrease in expression of ICAM-1 and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis. PMID: 19960256
5. results suggest that AT1R regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB into the nucleus PMID: 19940029
6. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin and p105(Cas-L) PMID: 11947929
7. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair. PMID: 12230506
8. spatial heterogeneity of MAdCAM-1 and VCAM-1 activation following TNF-alpha challenge may promote specific T lymphocyte recruitment in the inflamed colonic mucosa PMID: 12388196
9. Increased expression of mucosal addressin cell adhesion molecule-1 in gastritis induced by Helicobacter pylori PMID: 12390304
10. expression of MAdCAM-1 by fibroblasts and melanomas suggests MAdCAM-1 may play a role in regulating host responses in the periphery, leucocyte transmigration across nonendothelial boundaries, or the homotypic interactions of some malignant melanomas PMID: 12848854
11. GST-3 is responsible for MECA-79 (MADCAM1)defined luminal ligands PMID: 15111310
12. MAdCAM-1 plays important roles in T-lymphocyte adherence in all intestinal sites. PMID: 15371130
13. In a chronic ileitis model, pathogenic CD4+ T cells use the MAdCAM-1/alpha4beta7 physiologic pathway in order to recirculate to the chronically inflamed small intestine. PMID: 15699171
14. In wild-type mice administered blocking monoclonal antibody (mAb) to VCAM1-1 but nor to Madcam1 recruitment of mast cells to the inflamed lung was not reduced. PMID: 16670268
15. These data indicate that TNF-alpha deficiency alters homoeostasis of the colonic chemokine/cytokine environment and humoral immune response, resulting in an exacerbation of acute DSS-induced colitis in TNF-alpha(-/-) mice. PMID: 17768420
16. Combined effects of diabetes and pregnancy on pancreatic and decidual expression of VCAM-1, MAdCAM-1 and PNAd. PMID: 18031809
17. Expression of MAdCAM-1 in isolated lymphoid follicles (ILFs) of the small intestine colocalizes with CD31 expression, indicating that MAdCAM-1 expression in ILFs is restricted to vascular structures. PMID: 18768861

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Absence of Madcam1 in the spleen has been found in aly/aly mice, but normal expression is found in intestinal venules. This aberrant expression is a secondary defect and not the direct cause of aly alymphoplasia, an autosomal recessive mutation which induces total aplasia of lymph nodes and Peyer patches.

Membrane; Single-pass type I membrane protein.

Highly expressed on high endothelial venules (HEV) of organized intestinal lymphoid tissues like the Peyer patches and mesenteric lymph nodes, and in the lamina propria of the intestine. Some expression found in the spleen, and low levels of expression in

STRING: 10090.ENSMUSP00000020554

UniGene: Mm.391556