MADCAM1
MAdCAM-1（粘膜血管地址素細(xì)胞粘附分子1）是免疫球蛋白超家族的一員，作為一種跨膜蛋白，它在腸道粘膜淋巴組織的血管內(nèi)皮細(xì)胞上選擇性表達(dá)。MAdCAM-1的結(jié)構(gòu)包含三個(gè)免疫球蛋白樣結(jié)構(gòu)域和一個(gè)粘蛋白樣區(qū)域，其中前兩個(gè)結(jié)構(gòu)域能夠與淋巴細(xì)胞的歸巢受體α4β7結(jié)合，而粘蛋白樣結(jié)構(gòu)域則與選擇素L結(jié)合。它主要參與淋巴細(xì)胞的歸巢過(guò)程，通過(guò)與其歸巢受體的相互作用，引導(dǎo)淋巴細(xì)胞向粘膜部位定向遷移。此外，MAdCAM-1還在炎癥反應(yīng)中發(fā)揮重要作用，通過(guò)調(diào)節(jié)白細(xì)胞在粘膜環(huán)境中的通過(guò)和保留，影響炎癥的發(fā)展。因此，MAdCAM-1在維持機(jī)體內(nèi)淋巴細(xì)胞遷移和炎癥調(diào)節(jié)中起到關(guān)鍵作用，成為治療炎癥性腸病等疾病的重要靶點(diǎn)。
熱銷(xiāo)產(chǎn)品
Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial (CSB-YP618776HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MADCAM1 Antibodies
MADCAM1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 種屬反應(yīng)性 | 應(yīng)用類(lèi)型 |
|---|---|---|---|
| CSB-PA295662 | MADCAM1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA618776HA01HU | MADCAM1 Antibody | Human | ELISA, WB, IF |
| CSB-PA618776HB01HU | MADCAM1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA618776HC01HU | MADCAM1 Antibody, FITC conjugated | Human | |
| CSB-PA618776HD01HU | MADCAM1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA215817A0HU | MADCAM1 Recombinant Monoclonal Antibody | Human | ELISA, FC |
MADCAM1 Proteins
MADCAM1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱(chēng) | 來(lái)源 |
|---|---|---|
| CSB-YP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Yeast |
| CSB-EP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | E.coli |
| CSB-BP618776HU CSB-EP618776HU-B |
Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP618776HU | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Mammalian cell |
| CSB-YP618776HUc7 | Recombinant Human Mucosal addressin cell adhesion molecule 1 (MADCAM1), partial | Yeast |
