Mouse Macrophage mannose receptor 1(MRC1) ELISA kit
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中文名稱：小鼠巨噬細(xì)胞甘露糖受體1(MRC1)酶聯(lián)免疫試劑盒
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貨號：CSB-EL014782MO
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規(guī)格：96T/48T
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價(jià)格：￥3600/￥2500
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：小鼠巨噬細(xì)胞甘露糖受體1(MRC1)酶聯(lián)免疫試劑盒（CSB-EL014782MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細(xì)胞裂解物樣本中的MRC1含量。MRC1是巨噬細(xì)胞上的甘露糖受體，參與先天免疫，識別并結(jié)合病原體表面的甘露糖結(jié)構(gòu)，介導(dǎo)巨噬細(xì)胞對病原體的吞噬作用。研究顯示，MRC1在腫瘤微環(huán)境中發(fā)揮重要作用，其表達(dá)與腫瘤進(jìn)展和轉(zhuǎn)移密切相關(guān)。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，特別適用于評估巨噬細(xì)胞極化狀態(tài)、腫瘤免疫微環(huán)境分析以及自身免疫性疾病模型中受體表達(dá)動態(tài)變化的研究本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
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別名：Mrc1 ELISA Kit; Macrophage mannose receptor 1 ELISA Kit; MMR ELISA Kit; CD antigen CD206 ELISA Kit
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縮寫：
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Uniprot No.：
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種屬：Mus musculus (Mouse)
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樣本類型：serum, plasma, tissue homogenates, cell lysates
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檢測范圍：0.625 ng/mL-40 ng/mL
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靈敏度：0.156 ng/mL
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反應(yīng)時(shí)間：1-5h
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樣本體積：50-100ul
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檢測波長：450 nm
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研究領(lǐng)域：Immunology
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測定原理：quantitative
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測定方法：Sandwich
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精密度：
Intra-assay Precision (Precision within an assay): CV%<8% Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV%<10% Three samples of known concentration were tested in twenty assays to assess. -
線性度：
To assess the linearity of the assay, samples were spiked with high concentrations of mouse MRC1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay. Sample Serum(n=4) 1:1 Average % 88 Range % 81-92 1:2 Average % 100 Range % 93-104 1:4 Average % 90 Range % 85-95 1:8 Average % 99 Range % 91-103 -
回收率：
The recovery of mouse MRC1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section. Sample Type Average % Recovery Range Serum (n=5) 92 85-96 EDTA plasma (n=4) 100 90-104 -
標(biāo)準(zhǔn)曲線：
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed. 
ng/ml OD1 OD2 Average Corrected 40 2.716 2.578 2.647 2.462 20 2.167 2.187 2.177 1.992 10 1.451 1.478 1.465 1.280 5 0.857 0.823 0.840 0.655 2.5 0.536 0.545 0.541 0.356 1.25 0.371 0.359 0.365 0.180 0.625 0.274 0.266 0.270 0.085 0 0.188 0.182 0.185 -
數(shù)據(jù)處理：
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貨期：3-5 working days
引用文獻(xiàn)
- Einsatz des Modellorganismus Galleria mellonella zur Bestimmung neuer Therapieans?tze bei Infektionen – Untersuchungen auf Basis einer Transkriptom Sequenzierung LA Nagel,der Eberhard Karls Universit?t,/
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相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
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基因功能參考文獻(xiàn)：
- findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium PMID: 28317806
- current study shows that Mrc1-/- mice develop less severe dextran sulfate sodium-induced colitis PMID: 26530135
- the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation. PMID: 27405760
- PLA2 may prevent inflammatory responses in cisplatin-induced acute kidney injury by modulating Treg cells and IL-10 through the CD206 mannose receptor. PMID: 25993317
- Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection. PMID: 26216935
- CD206-positive pulmonary macrophages have a critical role in triggering inflammatory cascade during endotoxemic lung inflammation PMID: 25447055
- These findings suggest that MR plays a major role in Enterococcus faecalis strain EC-12 phagocytosis by the antigen-presenting cells. PMID: 23801521
- Genetic ablation of the Mrc1 impaired the intracellular collagen degradation pathway. PMID: 24019537
- Report CD44/macrophage mannose receptor as a ligand/receptor pair involved in the process of lymphocyte transit via the lymphatic vasculature. PMID: 23603511
- study reports the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors signature composed of Dectin-1, mannose receptor (MR)and the DC-SIGN homolog SIGNR3 expression PMID: 23684988
- These findings suggest that MRC1 plays an important role in the uptake of various bacteria by trophoblast giant cells and may provide an opportunity for those bacteria to escape from phagosomes. PMID: 23163874
- The results suggest that MRC1 plays a critical role in myeloid plasticity, which in turn affects the adaptive immune response and immunopathogenesis during murine neurocysticercosis. PMID: 23319563
- CD206 is an pattern recognition receptor in detection of the infective Schistosoma mansoni and modulates IFNgamma production. PMID: 22036898
- Data show that MR polyubiquitination mediates the recruitment of p97 toward the endosomal membrane, proving the central role of the endocytic receptor and its ubiquitination in antigen translocation. PMID: 21628571
- The mannose receptor (MR) is the primary receptor mediating the internalization of environmental allergen glycoproteins by dendritic cells. Signals originating from the MR and TLR-2 receptors converge with the notch 1 signalling pathway. PMID: 20819091
- MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72. PMID: 15746201
- macrophage mannose receptor lectin activities are influenced by glycosylation PMID: 15983039
- These data identify a novel function for mannose receptor (MR) during skeletal muscle growth and suggest that myoblast motility may be a key aspect of regulating myotube growth. PMID: 16864654
- Study explores Ptgs1 and Mrc1 genes as two new positional candidate genes for allergen-induced airway hyperresponsiveness through comparative sequence analysis and mRNA expression studies of mouse strains with genetically mediated airway responsiveness. PMID: 17454003
- The role of the mannose receptor in C. neoformans infection in wild-type and knockout mice is reported. PMID: 18391001
- This study provides a profile of MR N-linked glycosylation that will facilitate our understanding of their physiological role on MR biology in vivo. PMID: 19427834
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亞細(xì)胞定位：Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
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組織特異性：Detected in macrophages.
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