Recombinant Mouse Macrophage mannose receptor 1 (Mrc1), partial

中文名稱：

小鼠Mrc1重組蛋白
貨號：

CSB-YP723429MO
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

小鼠Mrc1重組蛋白
貨號：

CSB-EP723429MO
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

小鼠Mrc1重組蛋白
貨號：

CSB-EP723429MO-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

小鼠Mrc1重組蛋白
貨號：

CSB-BP723429MO
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

小鼠Mrc1重組蛋白
貨號：

CSB-MP723429MO
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Mrc1
Uniprot No.：

Q61830
別名：

Mrc1; Macrophage mannose receptor 1; MMR; CD antigen CD206
種屬：

Mus musculus (Mouse)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.
基因功能參考文獻：
1. findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium PMID: 28317806
2. current study shows that Mrc1-/- mice develop less severe dextran sulfate sodium-induced colitis PMID: 26530135
3. the key roles of the ManR and ASGR in controlling circulating levels of numerous glycoproteins critical for regulating reproductive hormones and blood coagulation. PMID: 27405760
4. PLA2 may prevent inflammatory responses in cisplatin-induced acute kidney injury by modulating Treg cells and IL-10 through the CD206 mannose receptor. PMID: 25993317
5. Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection. PMID: 26216935
6. CD206-positive pulmonary macrophages have a critical role in triggering inflammatory cascade during endotoxemic lung inflammation PMID: 25447055
7. These findings suggest that MR plays a major role in Enterococcus faecalis strain EC-12 phagocytosis by the antigen-presenting cells. PMID: 23801521
8. Genetic ablation of the Mrc1 impaired the intracellular collagen degradation pathway. PMID: 24019537
9. Report CD44/macrophage mannose receptor as a ligand/receptor pair involved in the process of lymphocyte transit via the lymphatic vasculature. PMID: 23603511
10. study reports the macrophage response against Leishmania infantum in vivo is characterized by an M2b-like phenotype and C-type lectin receptors signature composed of Dectin-1, mannose receptor (MR)and the DC-SIGN homolog SIGNR3 expression PMID: 23684988
11. These findings suggest that MRC1 plays an important role in the uptake of various bacteria by trophoblast giant cells and may provide an opportunity for those bacteria to escape from phagosomes. PMID: 23163874
12. The results suggest that MRC1 plays a critical role in myeloid plasticity, which in turn affects the adaptive immune response and immunopathogenesis during murine neurocysticercosis. PMID: 23319563
13. CD206 is an pattern recognition receptor in detection of the infective Schistosoma mansoni and modulates IFNgamma production. PMID: 22036898
14. Data show that MR polyubiquitination mediates the recruitment of p97 toward the endosomal membrane, proving the central role of the endocytic receptor and its ubiquitination in antigen translocation. PMID: 21628571
15. The mannose receptor (MR) is the primary receptor mediating the internalization of environmental allergen glycoproteins by dendritic cells. Signals originating from the MR and TLR-2 receptors converge with the notch 1 signalling pathway. PMID: 20819091
16. MR+ macrophages, surrounding early decidual glands, are able to internalize ligands for carbohydrate recognition domain of the receptor, including decidual secretory phase mucin TAG-72. PMID: 15746201
17. macrophage mannose receptor lectin activities are influenced by glycosylation PMID: 15983039
18. These data identify a novel function for mannose receptor (MR) during skeletal muscle growth and suggest that myoblast motility may be a key aspect of regulating myotube growth. PMID: 16864654
19. Study explores Ptgs1 and Mrc1 genes as two new positional candidate genes for allergen-induced airway hyperresponsiveness through comparative sequence analysis and mRNA expression studies of mouse strains with genetically mediated airway responsiveness. PMID: 17454003
20. The role of the mannose receptor in C. neoformans infection in wild-type and knockout mice is reported. PMID: 18391001
21. This study provides a profile of MR N-linked glycosylation that will facilitate our understanding of their physiological role on MR biology in vivo. PMID: 19427834
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亞細胞定位：

Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.
組織特異性：

Detected in macrophages.
數據庫鏈接：

KEGG: mmu:17533

STRING: 10090.ENSMUSP00000028045

UniGene: Mm.2019