TNFRSF1B
TNFRSF1B（TNF receptor superfamily member 1b）為TNF受體超家族成員，也稱為TNFR2，主要表達(dá)在腫瘤微環(huán)境中的Treg細(xì)胞和多種腫瘤細(xì)胞中（如卵巢癌和腸癌）。TNFR2與受體TNF結(jié)合后，通過激活典型和非典型的NF-kB通路來控制細(xì)胞的生存和增殖。大量研究顯示，TNFR2抑制劑能夠特異性抑制在腫瘤微環(huán)境中高表達(dá)TNFR2的Tregs的功能，同時(shí)特異性殺傷腫瘤細(xì)胞，用于抗腫瘤治療；而TNFR2激活劑則可以激活Tregs細(xì)胞，抑制效應(yīng)性T細(xì)胞（Teff），進(jìn)而下調(diào)免疫反應(yīng)，可以用于自身免疫疾病治療。隨著對(duì)于新靶點(diǎn)的不斷深入挖掘，TNFR2的重要性日漸受到關(guān)。TNFR2已經(jīng)成為免疫逃逸、腫瘤生長(zhǎng)以及檢查點(diǎn)阻斷抵抗性的潛在誘因。TNFR2抑制劑抗體則能夠抑制腫瘤相關(guān)Tregs的增殖和功能。
Recombinant Human TNFRSF1B 活性蛋白實(shí)驗(yàn)驗(yàn)證數(shù)據(jù)
by SDS-PAGE
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized TNF-α (CSB-YP023955HU) at 5 μg/ml can bind human TNFR2, the EC50 of human TNFR2 protein is 1.162-1.481 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized LTA (CSB-MP013218HU) at 5 μg/ml can bind human TNFRSF1B, the EC50 is 1.632-2.699 ng/ml.
TNFRSF1B Antibodies
TNFRSF1B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA023978GA01HU | TNFRSF1B Antibody | Human | ELISA,WB,IHC |
| CSB-PA949730 | TNFRSF1B Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA004309 | TNFRSF1B Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA229503 | TNFRSF1B Antibody | Human | ELISA,WB,IHC |
| CSB-PA234429 | TNFRSF1B Antibody | Human | ELISA,WB |
TNFRSF1B Proteins
TNFRSF1B Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP023978MO1 CSB-EP023978MO1 CSB-BP023978MO1 CSB-MP023978MO1 CSB-EP023978MO1-B |
Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF023978MO | Recombinant Mouse Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b) | in vitro E.coli expression system |
TNFRSF1B Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP800353RA CSB-EP800353RA CSB-BP800353RA CSB-MP800353RA CSB-EP800353RA-B |
Recombinant Rat Tumor necrosis factor receptor superfamily member 1B (Tnfrsf1b), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TNFRSF1B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP023978HU1 | Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial | E.coli |
| CSB-AP002371HU | Recombinant Human Tumor necrosis factor receptor superfamily member 1B protein (TNFRSF1B), partial (Active) | E.Coli |
| CSB-CF023978HU | Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) | in vitro E.coli expression system |
| CSB-YP023978HU2 | Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial | Yeast |
| CSB-AP004891HU | Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial (Active) | Mammalian cell |
| CSB-MP023978HU2 | Recombinant Human Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), partial (Active) | Mammalian cell |
TNFRSF1B ELISA Kit
TNFRSF1B ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11266h | Human soluble tumor necrosis factor receptor 2,sTNF-R2 ELISA Kit | serum, plasma, tissue homogenates | 7.8 pg/mL |
TNFRSF1B ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04739m | Mouse Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA KIT | serum, plasma, tissue homogenates | 1.6 pg/mL |
TNFRSF1B ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07380r | Rat Tumor necrosis factor soluble receptor Ⅱ,TNFsR-Ⅱ ELISA KIT | serum, plasma, tissue homogenates | 0.156 ng/mL |
