STAT5A
STAT5A，即信號轉(zhuǎn)導(dǎo)和轉(zhuǎn)錄激活因子5A，別名STAT5A1、MGF、STAT5。它是一種由STAT5A基因編碼的轉(zhuǎn)錄因子，屬于STAT蛋白家族成員，在多種細(xì)胞類型中表達(dá)。STAT5A的作用機制涉及響應(yīng)細(xì)胞因子或生長因子的刺激，通過JAK激酶磷酸化激活，進而形成二聚體并轉(zhuǎn)移到細(xì)胞核內(nèi)，調(diào)控下游基因的表達(dá)。STAT5A參與調(diào)節(jié)細(xì)胞增殖、分化、凋亡、乳汁分泌、免疫反應(yīng)等多種生理過程。STAT5A的功能異常與多種疾病有關(guān)，包括癌癥、免疫缺陷和發(fā)育異常，是藥物開發(fā)和相關(guān)疾病治療中的潛在靶點。
熱銷產(chǎn)品
Phospho-STAT5A (Y694) Recombinant Monoclonal Antibody (CSB-RA022814A694phHU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in HepG2 whole cell lysate(treated with EGF or not)
All lanes Phospho-STAT5A antibody at 1.025μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 90 KDa
Observed band size: 90 KDa
IHC image of CSB-RA022814A694phHU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
STAT5A Antibodies
STAT5A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA022814GA01HU | STAT5A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA877372 | Phospho-STAT5A (Tyr694) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA137661 | Phospho-STAT5A (Ser780) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA094290 | STAT5A (Ab-694) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA103883 | STAT5A (Ab-780) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA052847 | STAT5A Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004179 | STAT5A Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA004180 | STAT5A Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA050167 | Phospho-STAT5A (S780) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
| CSB-PA080243 | STAT5A Antibody | Human | WB, IHC |
| CSB-PA080262 | STAT5A Antibody | Rat,Mouse | WB, IHC |
| CSB-PA554957 | STAT5A Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-RA022814A694phHU | Phospho-STAT5A (Y694) Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
STAT5A Proteins
STAT5A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814HU CSB-EP022814HU CSB-BP022814HU CSB-MP022814HU CSB-EP022814HU-B |
Recombinant Human Signal transducer and activator of transcription 5A (STAT5A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT5A Proteins for Ovis aries (Sheep)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814SH CSB-EP022814SH CSB-BP022814SH CSB-MP022814SH CSB-EP022814SH-B |
Recombinant Sheep Signal transducer and activator of transcription 5A (STAT5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT5A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814MO CSB-EP022814MO CSB-BP022814MO CSB-MP022814MO CSB-EP022814MO-B |
Recombinant Mouse Signal transducer and activator of transcription 5A (Stat5a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT5A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814RA CSB-EP022814RA CSB-BP022814RA CSB-MP022814RA CSB-EP022814RA-B |
Recombinant Rat Signal transducer and activator of transcription 5A (Stat5a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT5A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814BO CSB-EP022814BO CSB-BP022814BO CSB-MP022814BO CSB-EP022814BO-B |
Recombinant Bovine Signal transducer and activator of transcription 5A (STAT5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT5A Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP022814PI CSB-EP022814PI CSB-BP022814PI CSB-MP022814PI CSB-EP022814PI-B |
Recombinant Pig Signal transducer and activator of transcription 5A (STAT5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
