SELP

SELP，全稱(chēng)為selectin P (granule membrane protein 140kDa, antigen CD62)，是一種存在于血小板α顆粒和內(nèi)皮細(xì)胞Weibel-Palade小體中的跨膜糖蛋白。它也被稱(chēng)為P-選擇素、GMP140、CD62P等。SELP蛋白在炎癥反應(yīng)中發(fā)揮著重要作用，介導(dǎo)中性粒細(xì)胞和單核細(xì)胞與內(nèi)皮細(xì)胞的初始粘附相互作用；在止血過(guò)程中，活化的血小板與中性粒細(xì)胞和單核細(xì)胞相互作用。SELP蛋白的表達(dá)和功能與多種疾病的發(fā)生發(fā)展密切相關(guān)，包括腎臟疾病、甲狀腺疾病、腫瘤等。近年來(lái)，研究發(fā)現(xiàn)SELP蛋白參與了多種腎臟疾病的病理生理過(guò)程，如腎缺血再灌注損傷、糖尿病腎病、慢性腎臟病及腎癌等。SELP蛋白的抗氧化活性可能在腎臟疾病的防治中發(fā)揮重要作用。此外，SELP蛋白的表達(dá)和功能也與甲狀腺疾病、腫瘤等密切相關(guān)。在藥物研發(fā)方面，針對(duì)SELP蛋白的抗體和重組蛋白等已被廣泛應(yīng)用于基礎(chǔ)研究和臨床診斷中，并成為潛在的治療靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human P-selectin (SELP), partial (CSB-MP020978HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

SELP Antibody (CSB-PA020978LA01HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of HepG2 cells with CSB-PA020978LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human P-Selectin ELISA kit (CSB-E04708h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E04708h

規(guī)格：96T/48T

靈敏度：0.225 ng/mL

檢測(cè)范圍：0.9 ng/mL-60 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

SELP Antibody

SELP Protein

SELP ELISA Kit

SELP Antibodies

SELP for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA006202	SELP Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA020978LA01HU	SELP Antibody	Human	ELISA, IF
CSB-PA020978LB01HU	SELP Antibody, HRP conjugated	Human	ELISA
CSB-PA020978LC01HU	SELP Antibody, FITC conjugated	Human
CSB-PA020978LD01HU	SELP Antibody, Biotin conjugated	Human	ELISA

SELP Proteins

SELP Proteins for Ovis aries (Sheep)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP020978SH1 CSB-EP020978SH1 CSB-BP020978SH1 CSB-MP020978SH1 CSB-EP020978SH1-B	Recombinant Sheep P-selectin (SELP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF020978SH	Recombinant Sheep P-selectin (SELP)	in vitro E.coli expression system

SELP Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP020978RA1 CSB-EP020978RA1 CSB-BP020978RA1 CSB-MP020978RA1 CSB-EP020978RA1-B	Recombinant Rat P-selectin (Selp), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF020978RA	Recombinant Rat P-selectin (Selp)	in vitro E.coli expression system

SELP Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP020978MO1 CSB-EP020978MO1 CSB-BP020978MO1 CSB-MP020978MO1 CSB-EP020978MO1-B	Recombinant Mouse P-selectin (Selp), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF020978MO	Recombinant Mouse P-selectin (Selp)	in vitro E.coli expression system

SELP Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP020978BO1 CSB-EP020978BO1 CSB-BP020978BO1 CSB-MP020978BO1 CSB-EP020978BO1-B	Recombinant Bovine P-selectin (SELP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF020978BO	Recombinant Bovine P-selectin (SELP)	in vitro E.coli expression system