RUNX1
RUNX1，即Runt相關轉錄因子1，別名AML1、CBFA2、Runt-related transcription factor 1。它是一種由人類染色體21q22.3位置上的基因編碼的轉錄因子，屬于RUNX轉錄因子家族成員之一。RUNX1的作用機制涉及與DNA結合以及形成異源二聚體，其中RUNX1蛋白包含Runt同源結構域（RHD），能夠介導與CBFβ構成異源二聚體并促進與DNA的結合，從而調控多種基因的表達。
RUNX1對于維持正常造血功能至關重要，它參與細胞分化、增殖、細胞周期、DNA修復、凋亡等多種生物學過程。RUNX1基因的突變可見于多種血液腫瘤，尤其在骨髓增生異常綜合征（MDS）和急性髓細胞白血病（AML）中發生頻率較高，并提示患者預后不良。RUNX1的異常表達或功能喪失與腫瘤發生發展有關，是髓系腫瘤研究中的關鍵分子之一。
熱銷產品
Recombinant Human Runt-related transcription factor 1 (Runx1) (CSB-EP020592HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數據
Western blot analysis of extract from P19, Hela and 293 cells using AML1(RUNX1) Antibody
RUNX1 Antibodies
RUNX1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA020592GA01HU | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA245126 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA570589 | Phospho-RUNX1 (Ser276) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA126379 | Phospho-RUNX1 (Ser303) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA110286 | Phospho-RUNX1 (Ser435) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA132524 | RUNX1 (Ab-435) Antibody | Human,Mouse | ELISA,WB |
| CSB-PA070101 | Phospho-RUNX1 (S249) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070102 | Phospho-RUNX1 (S435) Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070103 | Phospho-RUNX1 (S276) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA070104 | RUNX1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA070106 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA010571 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA161481 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA020592LA01HU | RUNX1 Antibody | Human | ELISA, WB, IF |
| CSB-PA020592LB01HU | RUNX1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA020592LC01HU | RUNX1 Antibody, FITC conjugated | Human | |
| CSB-PA020592LD01HU | RUNX1 Antibody, Biotin conjugated | Human | ELISA |
RUNX1 Proteins
RUNX1 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020592RA CSB-MP020592RA CSB-EP020592RA-B |
Recombinant Rat Runt-related transcription factor 1 (Runx1) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | E.coli |
| CSB-BP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | Baculovirus |
RUNX1 Proteins for Xenopus laevis (African clawed frog)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP020592XBE CSB-EP020592XBE CSB-BP020592XBE CSB-MP020592XBE CSB-EP020592XBE-B |
Recombinant Xenopus laevis Runt-related transcription factor 1 (runx1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RUNX1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP020592HU | Recombinant Human Runt-related transcription factor 1 (Runx1) | E.coli |
