P2RX3
P2RX3，即嘌呤能受體P2X配體門控離子通道3型蛋白，常被稱為P2X3受體，別名P2X3。P2RX3屬于ATP門控的非選擇性陽離子通道家族，主要分布于感覺神經元末梢，通過與胞外ATP結合觸發鈉、鈣離子內流，參與痛覺信號傳導及內臟器官的神經反射調控。研究發現，其過度激活與慢性咳嗽、膀胱過度活動癥及糖尿病神經病變密切相關，在神經源性炎癥和內臟超敏反應中起關鍵作用。近年來針對P2X3受體的藥物開發取得突破，如首個高選擇性拮抗劑Gefapixant（AF-219）已完成Ⅲ期臨床試驗，證實能顯著改善難治性慢性咳嗽患者癥狀，但存在味覺障礙副作用。另有Eliapixant（BAY-1817080）等二代藥物通過結構優化降低不良反應，目前處于Ⅱ期研究階段。該靶點同時被探索用于治療間質性膀胱炎和神經病理性疼痛，其雙重拮抗劑（同時阻斷P2X2/3異源三聚體）在腸易激綜合征等疾病中展現出潛在治療價值。
熱銷產品
P2RX3 Antibody (CSB-PA017321ESR1HU)
驗證數據
Western blot
All lanes: P2RX3 antibody at 3.91 μg/ml + Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 44 kDa
Observed band size: 44 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017321ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA017321ESR1HU at dilution of 1:100
P2RX3 Antibodies
P2RX3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005140 | P2RX3 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA056352 | P2RX3 Antibody | Human | ELISA,WB,IHC |
| CSB-PA017321ESR1HU | P2RX3 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA017321ESR2HU | P2RX3 Antibody | Human | ELISA, IHC |
P2RX3 Proteins
P2RX3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017321RA CSB-EP017321RA CSB-BP017321RA CSB-MP017321RA CSB-EP017321RA-B |
Recombinant Rat P2X purinoceptor 3 (P2rx3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
P2RX3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP017321HU CSB-EP017321HU CSB-BP017321HU CSB-MP017321HU CSB-EP017321HU-B |
Recombinant Human P2X purinoceptor 3 (P2RX3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
P2RX3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP663676MO CSB-EP663676MO CSB-BP663676MO CSB-MP663676MO CSB-EP663676MO-B |
Recombinant Mouse P2X purinoceptor 3 (P2rx3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
