P2RX3 Antibody
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中文名稱：P2RX3兔多克隆抗體
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貨號：CSB-PA005140
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規格：￥1090
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圖片：
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Western Blot analysis of K562 cells using P2X3 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：ATP receptor antibody; MGC129956 antibody; P2rx3 antibody; P2RX3_HUMAN antibody; P2X purinoceptor 3 antibody; P2X receptor subunit 3 antibody; P2X3 antibody; Purinergic receptor antibody; Purinergic receptor P2X ligand gated ion channel 3 antibody; Purinergic receptor P2X3 antibody; Purinoceptor P2X3 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human P2X3.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for ATP that acts as a ligand-gated cation channel. Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception.
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基因功能參考文獻：
- Druggable negative allosteric site of P2X3 receptors. PMID: 29674445
- conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R PMID: 26825305
- P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain. PMID: 28898282
- P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy. PMID: 26738991
- X-ray crystal structures of the human P2X3 receptor in apo/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states PMID: 27626375
- there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients. PMID: 27312548
- Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel. PMID: 27129281
- Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC) therapy. PMID: 26517690
- Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits PMID: 26184350
- Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection. PMID: 26241848
- The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder. PMID: 26253104
- sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns PMID: 24868547
- esophagitis increases mRNA expressions of P2X3 and P2X7 receptors accompanied by up-regulation of TRPV1 and neurotrophic factors (NGF and GDNF). PMID: 25336328
- Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening PMID: 24989924
- TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve PMID: 24764033
- Data indicate that Markov models are suitable to simulate agonist antagonist interactions at fast desensitizing receptors such as the P2X3R. PMID: 24223907
- ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis. PMID: 23917247
- An early and broad expression of P2X3 receptors was found in prenatal dorsal root ganglion neurons. PMID: 22052556
- HEK 293 cells are not permissive for stable P2X3 expression afer a significant time-dependent cell loss; often used in a recmbinant expression system, HEK cells represent a limiting permissive environment for P2X3 receptors. PMID: 22160848
- Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article] PMID: 22963434
- The effects of single alanine substitutions of amino acid residues in the supposed ATP binding site of the human P2X3 receptor on the agonistic effect of nucleotide analogs. PMID: 22498660
- one subunit of P2X2 and two subunits of P2X3 form P2X2/3 heteromeric receptors, whereas two subunits of P2X2 and one subunit of P2X6 constitute P2X2/6 receptors PMID: 22378790
- Amino acid residues constituting the agonist binding site of the human P2X3 receptor. PMID: 21098022
- P2X3 positive fibres in the trigeminal sensory system were significantly increased in burning mouth syndrome patients compared with controls. PMID: 20418063
- The present data indicate a novel target, P2X3 receptors, to express the action of Cdk5 on membrane proteins involved in pain perception. PMID: 19960242
- Released ATP activates P2X(3) receptors in the beta-cell plasma membrane, resulting in increased [Ca(2+)](i) and enhanced insulin secretion. PMID: 20308565
- P2X(1) receptors showed an anti-inflammatory effect reducing NF-kappaB activation and TNF-alpha release whilst P2X(3) receptors mediated opposite response. PMID: 20110693
- Review. Activation of P2X(3)-containing channels is an important mediator of persistent nociceptive signalling. The data also indicate potential discrete roles for homomeric P2X(3) & heteromeric P2X(2/3) receptor activation in acute & chronic pain. PMID: 12885270
- in fibers of human tooth pulp ... may play a role in perception of dental pain PMID: 14520770
- Effect of acute hypoxia on cloned homo- and heteromeric P2X3 receptors expressed in human embryonic kidney 293 cells. PMID: 15331767
- negative residues in the P2X3 ATP receptor ectodomain are structural determinants for desensitization and the Ca2+-sensing modulatory sites PMID: 15475563
- These data indicate that PKC activation can enhance both the Ca(2+) signal as well as the cation current through P2X(3)R, however it appears that the regulation is unlikely to be a result of direct phosphorylation of the receptor. PMID: 17052768
- genetic and pharmacological approaches have provided converging evidence that activation of P2X3-containing channels is an important mediator of acute and persistent nociceptive signaling--review PMID: 18600577
- Sodium Ferrulate may inhibit the initiation of pain and primary afferent sensitization mediated by P2X(3) receptor during chronic constriction injury. PMID: 18805451
- These cells expressed P2X3 receptors. Suburothelial myofibroblasts may be intermediate in processing adenosine triphosphate-mediated sensory activation PMID: 19456993
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：P2X receptor family
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