KRT8
KRT8，全稱為Keratin 8，是一種重要的細胞骨架蛋白，主要表達于上皮細胞的細胞質(zhì)中。該蛋白常見別名包括Cytokeratin-8 (CK-8)、Keratin-8 (K8)、Type-II keratin Kb8等。KRT8蛋白通常與KRT18蛋白形成異二聚體，共同參與構(gòu)成上皮細胞的中等大小細絲，維持細胞的形態(tài)和結(jié)構(gòu)穩(wěn)定性。KRT8蛋白在細胞信號傳導(dǎo)和細胞分化過程中也發(fā)揮著重要作用。KRT8蛋白的表達水平與多種疾病密切相關(guān)，如肺癌、慢性阻塞性肺疾病、哮喘、肺囊性纖維化等。在肺癌中，KRT8蛋白的表達與腫瘤的發(fā)生、發(fā)展和轉(zhuǎn)移密切相關(guān)。針對KRT8蛋白的藥物研發(fā)已取得一定進展，如抗KRT8抗體等，這些藥物有望成為治療相關(guān)疾病的新策略。
熱銷產(chǎn)品
Recombinant Human Keratin, type II cytoskeletal 8 (KRT8), partial (CSB-EP012574HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
KRT8 Recombinant Monoclonal Antibody (CSB-RA556953A0HU)
驗證數(shù)據(jù)
Immunofluorescence staining of Hela cell with CSB-RA556953A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Overlay Peak curve showing Hela cells stained with CSB-RA556953A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
KRT8 Antibodies
KRT8 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA012574GA01HU | KRT8 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA11269A0Rb | KRT8 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA091792 | Phospho-KRT8 (Ser74) Antibody | Human | ELISA,WB,IF |
| CSB-PA982739 | KRT8 (Ab-74) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA113927 | Phospho-KRT8 (Ser432) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA208261 | KRT8 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000118 | Acetyl-KRT8 (K483) Antibody | Human | WB, ELISA |
| CSB-PA000509 | Phospho-KRT8 (S73) Antibody | Human,Mouse | WB, IHC, ELISA |
| CSB-PA002052 | KRT8 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA002054 | KRT8 Antibody | Human,Mouse,Monkey | WB, IHC, IF, ELISA |
| CSB-PA005497 | KRT8 Antibody | Human | WB, ELISA |
| CSB-PA009661 | Phospho-KRT8 (S432) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA009662 | KRT8 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA579932 | KRT8 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA935926 | KRT8 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-MA999890 | KRT8 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA556953A0HU | KRT8 Recombinant Monoclonal Antibody | Human | ELISA, IF, FC |
KRT8 for H, M, R
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-MA000212 | KRT8 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
KRT8 Proteins
KRT8 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP012574HU CSB-BP012574HU CSB-MP012574HU CSB-EP012574HU-B |
Recombinant Human Keratin, type II cytoskeletal 8 (KRT8), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP012574HU | Recombinant Human Keratin, type II cytoskeletal 8 (KRT8), partial | E.coli |
| CSB-EP012574HU(A4) | Recombinant Human Keratin,type II cytoskeletal 8 (KRT8) | E.coli |
| CSB-BP012574HU(A4) | Recombinant Human Keratin, type II cytoskeletal 8 (KRT8) | Baculovirus |
