EIF2AK3
Eukaryotic translation initiation factor 2-alpha kinase 3 is a protein in humans that is encoded by EIF2AK3 gene. Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
EIF2AK3 Antibodies
EIF2AK3 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA007512GA01HU | EIF2AK3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA072558 | Phospho-EIF2AK3 (Thr981) Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA590642 | EIF2AK3 Antibody | Human | ELISA,WB,IF |
| CSB-PA000746 | Phospho-EIF2AK3 (T981) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA003739 | EIF2AK3 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA080010 | EIF2AK3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA071225 | EIF2AK3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA154507 | EIF2AK3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA007512LA01HU | EIF2AK3 Antibody | Human | ELISA, IHC, IF |
| CSB-PA007512LB01HU | EIF2AK3 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA007512LC01HU | EIF2AK3 Antibody, FITC conjugated | Human | |
| CSB-PA007512LD01HU | EIF2AK3 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA007512PA981phHU | Phospho-PERK(T981) Monoclonal Antibody | Human | ELISA, IF |
EIF2AK3 Proteins
EIF2AK3 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007512HU CSB-EP007512HU CSB-BP007512HU CSB-MP007512HU CSB-EP007512HU-B |
Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF2AK3 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007512MO CSB-EP007512MO CSB-BP007512MO CSB-MP007512MO CSB-EP007512MO-B |
Recombinant Mouse Eukaryotic translation initiation factor 2-alpha kinase 3 (Eif2ak3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
EIF2AK3 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP007512RA CSB-EP007512RA CSB-BP007512RA CSB-MP007512RA CSB-EP007512RA-B |
Recombinant Rat Eukaryotic translation initiation factor 2-alpha kinase 3 (Eif2ak3), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
