CXCR4
CXCR4：G蛋白耦聯受體（GPCR）家族，再出腫瘤免疫治療新藥！
趨化因子受體（C X C chemokine receptor 4，CXCR4）是一個具有7次跨膜結構的G蛋白耦聯受體。CXCR4作為GPCR家族中的一員，GPCR的超家族群已經被證明是許多藥物的藥理作用靶點。CXCR4在體內大部分組織和器官上都有表達，包括骨髓、臍血和動員的外周血來源的細胞表面，以及多種非造血干細胞表面表達。近年來研究發現，腫瘤細胞轉移到特定器官是不同器官通過趨化作用吸引特定類型腫瘤細胞歸巢的結果。在眾多的趨化因子受體中，CXCR4在許多腫瘤中都存在表達增強。目前的研究表明，與趨化因子受體CXCR4相關的癌癥超過23種，它還能促進血管生成，細胞的轉移、生長或生存。此外，還參與HIV病毒感染。這些生物學功能決定了CXCR4靶向藥可用于腫瘤、造血干細胞動員、HIV等疾病的治療。
CUSABIO-哺乳包膜VLPs平臺成功開發CXCR4全長膜蛋白（7次跨膜），展示了完整生物活性。
熱銷產品
Recombinant Human C-X-C chemokine receptor type 4(CXCR4)-VLPs (Active)（CSB-MP006254HU(F1)）
High Specificity Validated by Western Blot (WB)
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CSB-MP006254HU(F1) is detected by Mouse anti-6*His monoclonal antibody.
Excellent Bioactivity Validated by Functional ELISA
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Immobilized Human CXCR4 at 10 μg/ml can bind Anti-CXCR4 recombinant antibody (CSB-RA006254MA01HU), the EC50 is 101.7-253.6 ng/mL.
CXCR4 Antibodies
CXCR4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006254GA01HU | CXCR4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002588 | CXCR4 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA060127 | Phospho-CXCR4 (S339) Antibody | Human,Mouse,Rat,Monkey | WB, IHC, IF, ELISA |
| CSB-PA006254YA01HU | CXCR4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
| CSB-PA006254YB01HU | CXCR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA006254YC01HU | CXCR4 Antibody, FITC conjugated | Human | |
| CSB-PA006254YD01HU | CXCR4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA263860 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA996565 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA250029 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA099227 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-RA569311A0HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA, IF |
| CSB-RA006254MA01HU | CXCR4 Recombinant Monoclonal Antibody | Human | ELISA |
CXCR4 Proteins
CXCR4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254MO1 CSB-EP006254MO1 CSB-BP006254MO1 CSB-MP006254MO1 CSB-EP006254MO1-B |
Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MO | Recombinant Mouse C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254MOW1 CSB-EP006254MOW1 CSB-BP006254MOW1 CSB-MP006254MOW1 CSB-EP006254MOW1-B |
Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254MOW | Recombinant Macaca mulatta (Rhesus macaque) C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254BO1 CSB-EP006254BO1 CSB-BP006254BO1 CSB-MP006254BO1 CSB-EP006254BO1-B |
Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254BO | Recombinant Bovine C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254CA1 CSB-EP006254CA1 CSB-BP006254CA1 CSB-MP006254CA1 CSB-EP006254CA1-B |
Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254CA | Recombinant Cat C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254RA1 CSB-EP006254RA1 CSB-BP006254RA1 CSB-MP006254RA1 CSB-EP006254RA1-B |
Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254RA | Recombinant Rat C-X-C chemokine receptor type 4 (Cxcr4) | in vitro E.coli expression system |
CXCR4 Proteins for Papio anubis (Olive baboon)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254ERI1 CSB-EP006254ERI1 CSB-BP006254ERI1 CSB-MP006254ERI1 CSB-EP006254ERI1-B |
Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254ERI | Recombinant Papio anubis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Pan troglodytes (Chimpanzee)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254EQV1 CSB-EP006254EQV1 CSB-BP006254EQV1 CSB-MP006254EQV1 CSB-EP006254EQV1-B |
Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254EQV | Recombinant Pan troglodytes C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006254DRI1 CSB-EP006254DRI1 CSB-BP006254DRI1 CSB-MP006254DRI1 CSB-EP006254DRI1-B |
Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006254DRI | Recombinant Cercocebus atys C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP630683MOV1 CSB-EP630683MOV1 CSB-BP630683MOV1 CSB-MP630683MOV1 CSB-EP630683MOV1-B |
Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF630683MOV | Recombinant Macaca fascicularis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Ovis aries (Sheep)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP638935SH1 CSB-EP638935SH1 CSB-BP638935SH1 CSB-MP638935SH1 CSB-EP638935SH1-B |
Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF638935SH | Recombinant Sheep C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP668610DO1 CSB-EP668610DO1 CSB-BP668610DO1 CSB-MP668610DO1 CSB-EP668610DO1-B |
Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF668610DO | Recombinant Dog C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP755226PI1 CSB-EP755226PI1 CSB-BP755226PI1 CSB-MP755226PI1 CSB-EP755226PI1-B |
Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF755226PI | Recombinant Pig C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Tupaia chinensis (Chinese tree shrew)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP768744TDAE1 CSB-EP768744TDAE1 CSB-BP768744TDAE1 CSB-MP768744TDAE1 CSB-EP768744TDAE1-B |
Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF768744TDAE | Recombinant Tupaia chinensis C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Saimiri sciureus (Common squirrel monkey)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP810237SWD1 CSB-EP810237SWD1 CSB-BP810237SWD1 CSB-MP810237SWD1 CSB-EP810237SWD1-B |
Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF810237SWD | Recombinant Saimiri sciureus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Callithrix jacchus (White-tufted-ear marmoset)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP818191CYL1 CSB-EP818191CYL1 CSB-BP818191CYL1 CSB-MP818191CYL1 CSB-EP818191CYL1-B |
Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF818191CYL | Recombinant Callithrix jacchus C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP886927DSU1 CSB-EP886927DSU1 CSB-BP886927DSU1 CSB-MP886927DSU1 CSB-EP886927DSU1-B |
Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF886927DSU | Recombinant Chlorocebus aethiops C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-CF006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
| CSB-EP006254HU1 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-EP006254HU1e0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
| CSB-MP006254HU | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs | Mammalian cell |
| CSB-MP006254HU(F1) | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4)-VLPs (Active) | Mammalian cell |
| CSB-EP006254HU1c0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4), partial | E.coli |
CXCR4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-CF006254HUa0 | Recombinant Human C-X-C chemokine receptor type 4 (CXCR4) | in vitro E.coli expression system |
CXCR4 ELISA Kit
CXCR4 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12825h | Human CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, tissue homogenates | 0.39 pg/mL |
CXCR4 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E12703r | Rat CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
