CA9

碳酸酐酶IX（CA9）是一種跨膜鋅金屬酶，又稱G250或MN蛋白，在維持細胞酸堿平衡中起關鍵作用。該蛋白通過催化二氧化碳水合反應調(diào)節(jié)腫瘤微環(huán)境pH值，其表達受缺氧誘導因子HIF-1α調(diào)控，在透明細胞腎癌中呈現(xiàn)特異性高表達，約95%患者存在CA9過表達現(xiàn)象。作為重要的腫瘤相關抗原，CA9不僅參與PI3K/AKT等促生存信號傳導，還與血管生成、腫瘤轉(zhuǎn)移密切相關，其表達水平與腎癌、宮頸癌等多種實體瘤不良預后顯著相關。目前針對CA9開發(fā)的單克隆抗體Girentuximab已完成III期臨床，用于腎癌的放射性免疫顯像診斷；小分子抑制劑SLC-0111作為首款進入臨床試驗的CAIX靶向藥物，在乳腺癌、胰腺癌等適應癥的II期研究中顯示出聯(lián)合化療增效潛力。近年來基于CA9的CAR-T療法和DNA疫苗也進入臨床前研究階段。

熱銷產(chǎn)品

Recombinant Human Carbonic anhydrase 9 (CA9), partial (CSB-EP614990HUc0)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP614990HUc0 could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) CA9.

CA9 Recombinant Monoclonal Antibody (CSB-RA614990A0HU)

驗證數(shù)據(jù)

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-RA614990A0HU diluted at 1:118 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Carbonic Anhydrase 9(CA9) ELISA Kit (CSB-E13266h)

驗證數(shù)據(jù)

貨號：CSB-E13266h

規(guī)格：96T/48T

靈敏度：7.81 pg/mL

檢測范圍：31.25 pg/mL-2000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CA9 Antibody

CA9 Protein

CA9 ELISA Kit

CA9 Antibodies

CA9 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-PA004380GA01HU	CA9 Antibody	Human	ELISA,WB
CSB-PA614990GA01HU	CA9 Antibody	Human	ELISA,WB,IHC
CSB-PA001096	CA9 Antibody	Human	WB, ELISA
CSB-PA179189	CA9 Antibody	Human	ELISA,IHC
CSB-PA550152	CA9 Antibody	Human	ELISA,IHC
CSB-RA614990A0HU	CA9 Recombinant Monoclonal Antibody	Human	ELISA, IHC
CSB-PA614990LA01HU	CA9 Antibody	Human	ELISA, IHC
CSB-PA614990LB01HU	CA9 Antibody, HRP conjugated	Human	ELISA
CSB-PA614990LC01HU	CA9 Antibody, FITC conjugated	Human
CSB-PA614990LD01HU	CA9 Antibody, Biotin conjugated	Human	ELISA

CA9 for H

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應性	應用類型
CSB-MA000234	CA9 Monoclonal Antibody	Human	ELISA,WB,IP

CA9 Proteins

CA9 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP614990HU CSB-BP614990HU CSB-MP614990HU CSB-EP614990HU-B	Recombinant Human Carbonic anhydrase 9 (CA9), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP614990HU	Recombinant Human Carbonic anhydrase 9 (CA9), partial	E.coli
CSB-EP614990HUc0	Recombinant Human Carbonic anhydrase 9 (CA9), partial	E.coli

CA9 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP848704MO CSB-EP848704MO CSB-BP848704MO CSB-MP848704MO CSB-EP848704MO-B	Recombinant Mouse Carbonic anhydrase 9 (Ca9), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli