ILF3 Antibody

說明書

中文名稱：

ILF3兔多克隆抗體
貨號：

CSB-PA004643
規格：

￥1090
圖片：
Western Blot analysis of A549 K562 NIH-3T3 cells using NF90 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q12906
基因名：

ILF3
別名：

CBTF antibody; Double stranded RNA binding protein 76 antibody; Double-stranded RNA-binding protein 76 antibody; DRBF antibody; DRBP76 antibody; ILF3 antibody; ILF3_HUMAN antibody; Interleukin enhancer binding factor 3 antibody; Interleukin enhancer-binding factor 3 antibody; M phase phosphoprotein 4 antibody; M-phase phosphoprotein 4 antibody; MPHOSPH4 antibody; MPP4 antibody; NF AT 90 antibody; NF-AT-90 antibody; NF110 antibody; NF90 antibody; NFAR antibody; Nuclear factor associated with dsRNA antibody; Nuclear factor of activated T cells 90 kDa antibody; Nuclear factor of activated T-cells 90 kDa antibody; TCP80 antibody; Translational control protein 80 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human NF90.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.
基因功能參考文獻：
1. DNA- and RNA-binding protein NF90/ILF3/NF110 associates with chromatin to hierarchically regulate transcription factors that promote proliferation and suppress differentiation. PMID: 29590119
2. Reprot a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection. PMID: 28625552
3. The NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma cells, and NF90 is a potential target to inhibit PARP1 activity. PMID: 28487110
4. Variants in ILF3 gene is associated with thrombosis. PMID: 26908601
5. these data establish miR-590-5p as an anti-onco-miR that inhibits colorectal cancer angiogenesis and metastasis through a new mechanism involving NF90/VEGFA signaling axis. PMID: 27735951
6. NF90 exerts its antiviral activity by antagonizing the inhibitory role of NS1 on PKR phosphorylation PMID: 27423063
7. These data suggest that, like ADAR2, underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs PMID: 26712564
8. The NF90 C-terminus is involved in conformational changes in the protein after RNA binding. PMID: 26795062
9. Taken together, our discovery of the function of TCP80 and RHA in regulating p53 IRES and p53 induction following DNA damage provides a better understanding of the mechanisms that regulate IRES-mediated p53 translation in response to genotoxic stress. PMID: 26273641
10. data suggest that lncRNA SALNR modulates cellular senescence at least partly through changing NF90 activity PMID: 26491010
11. Data indicate the role of cyclin-dependent kinase inhibitor 1A (p21) and interleukin enhancer binding factor 3 (ILF3) pathway in mediating the anti-leukemic activity of sodium dichloroacetate (DCA) in oncoprotein p53null leukemic cells. PMID: 25544776
12. Suppression of NF90 caused a decrease in the half-life of cyclin E1 mRNA PMID: 25399696
13. the role of the human NF90 protein isoforms in DNA and RNA virus replication PMID: 25447144
14. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. PMID: 24623135
15. The function of NF90 in posttranscriptional gene regulation and microRNA biogenesis. [Review] PMID: 23965975
16. Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a. PMID: 22986534
17. contributes to maintaining low levels of senescence-associated secretory phenotype factors in non-senescent cells PMID: 23117626
18. The unique C-terminal region of ILF3/NF110 is important for promoting survivin expression and for high affinity binding to YM155. PMID: 22442257
19. high expression of ERCC1, XPB and ILF3 was observed in human epithelial ovarian cancer PMID: 21971700
20. These data suggest that DRBP76, via its association with VP35, exerts an anti-Ebola virus function. PMID: 21987769
21. The protein polymorphism of Ilf3/NF90 and the various subcellular localizations of their isoforms may partially explain the various functions previously reported for these proteins. PMID: 21811582
22. associations of rs2569512 of ILF3 to myocardial infarction among individuals stratified by the absence or presence of hypertension, diabetes mellitus and chronic kidney disease PMID: 21347509
23. Production of HIV particles is regulated by altering sub-cellular localization and dynamics of Rev induced by double-strand RNA binding protein. PMID: 21364984
24. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus. PMID: 21386893
25. The relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and myocardial infarction is influenced by the serum concentrations of high density lipoprotein cholesterol and low density lipoprotein cholesterol, respectively. PMID: 21468600
26. Data suggest that physiologic DRBP76 expression, isoform distribution and subcellular localization are profoundly altered upon malignant transformation. PMID: 20668518
27. Nuclear export of this protein is required for interleukin-2 mRNA stabilization. PMID: 12504009
28. Results describe the expression of four isoforms of nuclear factor 90, including NF110, by cDNA cloning and mass spectrometric analysis of proteins isolated from human cells PMID: 12946349
29. nuclear export of ILF3 is mediated by exportin-5 and minihelix-containing RNA PMID: 14570900
30. the multiple cellular functions, i.e., translation control, interleukin-2 enhancer binding, or cell division, of ILF3 are fulfilled by alternatively spliced isoforms. PMID: 14654356
31. NF90 and NF110 engage RNA differentially and translocate from the nucleus to the cytoplasm in mitosis PMID: 15811368
32. ADAR1 has the potential both to change information content through editing of mRNA and to regulate gene expression through interacting with NF90 PMID: 16055709
33. The human Nuclear Factor 90 c-terminal variant protein encoded by ILF3 interacts with Rev to inhibit Rev-mediated RNA transport. PMID: 17125513
34. Our results show that perturbation Tat/TAR RNA interaction by the dsRNA binding nuclear factor 90 protein is sufficient to inhibit transcriptional activation of HIV-1. PMID: 17565699
35. DRBP76/NF90 isoform facilitates VEGF expression by promoting VEGF mRNA loading onto polysomes PMID: 18039850
36. NFARs exert influence on mRNA trafficking and the modulation of translation rates and may constitute an innate immune translational surveillance mechanism important in host defense countermeasures against virus infection PMID: 18337511
37. MKP-1 upregulation by oxidative stress is potently influenced by increased mRNA stability and translation, mediated at least in part by the RNA-binding proteins HuR and NF90. PMID: 18490444
38. ILF-3, which has been known to regulate IL-2 expression in T cells, up-regulates synoviolin expression with GABPalpha in rheumatoid synovial cells PMID: 19116932
39. NF90 inhibits influenza virus replication during the early phase of infection through direct interaction with viral NP. PMID: 19494010
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亞細胞定位：

Nucleus, nucleolus. Cytoplasm. Nucleus.
組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 6038

OMIM: 603182

KEGG: hsa:3609

STRING: 9606.ENSP00000404121

UniGene: Hs.465885

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