SLC4A5 Antibody

中文名稱：

SLC4A5兔多克隆抗體
貨號：

CSB-PA874837LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate
All lanes: SLC4A5 antibody at 2.7μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 127, 125, 116, 109, 108, 114, 119 kDa
Observed band size: 127 kDa

Immunofluorescence staining of HepG2 cells with CSB-PA874837LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC4A5 Polyclonal antibody
Uniprot No.：

Q9BY07
基因名：

SLC4A5
別名：

Electrogenic sodium bicarbonate cotransporter 4 antibody; MGC129662 antibody; NBC4 antibody; NBCe2 antibody; S4A5_HUMAN antibody; SLC4A5 antibody; Solute carrier family 4 member 5 antibody; Solute carrier family 4 sodium bicarbonate cotransporter member 5 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Electrogenic sodium bicarbonate cotransporter 4 protein (1071-1137AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC4A5 Antibody (CSB-PA874837LA01HU)，的標記方式是Non-conjugated。對于SLC4A5 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA874837LB01HU	SLC4A5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA874837LC01HU	SLC4A5 Antibody, FITC conjugated
Biotin	CSB-PA874837LD01HU	SLC4A5 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH.
基因功能參考文獻：
1. NBCe2 activity is stimulated by an increase in intracellular sodium and is hyper-responsive in hRPTCs carrying HV SLC4A5 rs7571842 through an aberrant HNF4A-mediated mechanism PMID: 29642240
2. NBCe2 could be important in proximal kidney tubule apical sodium and bicarbonate cotransport under high-salt conditions. PMID: 26447209
3. we summarize the potential function of NBCe2 in the regulation of blood pressure, acid-base, and K(+) and Ca(2+) transport in the distal nephron--{REVIEW} PMID: 26136555
4. Data indicate that 2 SNPs in SLC4A5 (rs7571842 and rs10177833) showed highly significant results and large effects sizes. PMID: 22987918
5. The additive effect of rs10177833 of SLC4A5 on systolic blood pressure is statistically different between women with dark skin color and women with medium skin color (P = .0153). PMID: 22764636
6. Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5 PMID: 19384345
7. Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued). PMID: 12063394
8. These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear. PMID: 16365189
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亞細胞定位：

Apical cell membrane; Multi-pass membrane protein.
蛋白家族：

Anion exchanger (TC 2.A.31) family
組織特異性：

Highest expression observed in liver, spleen and testis; moderate expression in the choroid plexus, hippocampus, cerebrum and cerebellum of brain, and in kidney cortex and kidney medulla. Also observed in heart, pancreas, muscle, lung, placenta, stomach a
數據庫鏈接：

HGNC: 18168

OMIM: 606757

KEGG: hsa:57835

STRING: 9606.ENSP00000350475

UniGene: Hs.594099

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