Recombinant Human Rho guanine nucleotide exchange factor 9 (ARHGEF9)

中文名稱：

Recombinant Human Rho guanine nucleotide exchange factor 9(ARHGEF9)
貨號：

CSB-YP002057HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Rho guanine nucleotide exchange factor 9(ARHGEF9)
貨號：

CSB-EP002057HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Rho guanine nucleotide exchange factor 9(ARHGEF9)
貨號：

CSB-EP002057HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Rho guanine nucleotide exchange factor 9(ARHGEF9)
貨號：

CSB-BP002057HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Rho guanine nucleotide exchange factor 9(ARHGEF9)
貨號：

CSB-MP002057HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

ARHGEF9
Uniprot No.：

O43307
別名：

9630036L12Rik; A230067K14; ARHG9_HUMAN; Arhgef9; Cdc42 guanine nucleotide exchange factor (GEF) 9; Collybistin; collybistin I; EIEE8; HPEM 2; hPEM-2 collybistin; KIAA0424; mKIAA0424; OTTHUMP00000023424; OTTHUMP00000023425; OTTHUMP00000023427; PEM 2; PEM 2 homolog ; PEM-2 homolog; PEM2; Rac/Cdc42 guanine nucleotide exchange factor 9; Rho guanine nucleotide exchange factor 9; RP11 357C3.4; RP23 230K20.3
種屬：

Homo sapiens (Human)
蛋白長度：

Full length protein
表達區域：

1-516
氨基酸序列

MTLLITGDSI VSAEAVWDHV TMANRELAFK AGDVIKVLDA SNKDWWWGQI DDEEGWFPAS FVRLWVNQED EVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR DQMRANVINE IMSTERHYIK HLKDICEGYL KQCRKRRDMF SDEQLKVIFG NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI GPCFLEHQDG FWIYSEYCNN HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL TPVQKICKYP LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC KKDLIRRDIL YYKGRIDMDK YEVVDIEDGR DDDFNVSMKN AFKLHNKETE EIHLFFAKKL EEKIRWLRAF REERKMVQED EKIGFEISEN QKRQAAMTVR KVPKQKGVNS ARSVPPSYPP PQDPLNHGQY LVPDGIAQSQ VFEFTEPKRS QSPFWQNFSR LTPFKK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
基因功能參考文獻：
1. Autism spectrum disorder patient with the smallest inactivating deletion in the collybistin gene. PMID: 27238888
2. Collybistin forms a complex with mTOR and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism. PMID: 25898924
3. Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans. PMID: 25678704
4. Data indicate that ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy. PMID: 21633362
5. These results reveal that G(s) and G(q) signalings regulate hPEM-2 functions through PKA and c-Src in Neuro-2a neuroblastoma cells, respectively. PMID: 22033413
6. major regulator of GABAergic postsynaptic gephyrin clustering PMID: 21807943
7. Here we identified residues critical for interaction with gephyrin in the linker region between the SH3 and the DH domains of collybistin. PMID: 11727829
8. translocates gephyrin to submembrane microaggregates; collybistin mutation (G55A)is found in exon 2 of the ARHGEF9 gene in a patient with clinical symptoms of both hyperekplexia and epilepsy PMID: 15215304
9. Results show that hPEM-2 is a target protein of Smurf1. PMID: 18208356
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相關疾病：

Epileptic encephalopathy, early infantile, 8 (EIEE8)
亞細胞定位：

Cytoplasm. Cell junction, synapse, postsynaptic density.
組織特異性：

Detected in brain. Detected at low levels in heart.
數據庫鏈接：

HGNC: 14561

OMIM: 300429

KEGG: hsa:23229

STRING: 9606.ENSP00000253401

UniGene: Hs.54697