ARHGEF9 Antibody
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中文名稱：ARHGEF9兔多克隆抗體
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貨號：CSB-PA364661
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規(guī)格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA364661(ARHGEF9 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA364661(ARHGEF9 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue, human fetal brain tissue, Primary antibody: CSB-PA364661(ARHGEF9 Antibody) at dilution 1/950, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：ARHGEF9
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別名：9630036L12Rik antibody; A230067K14 antibody; ARHG9_HUMAN antibody; Arhgef9 antibody; Cdc42 guanine nucleotide exchange factor (GEF) 9 antibody; Collybistin antibody; collybistin I antibody; EIEE8 antibody; HPEM 2 antibody; hPEM-2 collybistin antibody; KIAA0424 antibody; mKIAA0424 antibody; OTTHUMP00000023424 antibody; OTTHUMP00000023425 antibody; OTTHUMP00000023427 antibody; PEM 2 antibody; PEM 2 homolog antibody; PEM-2 homolog antibody; PEM2 antibody; Rac/Cdc42 guanine nucleotide exchange factor 9 antibody; Rho guanine nucleotide exchange factor 9 antibody; RP11 357C3.4 antibody; RP23 230K20.3 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human ARHGEF9
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 WB 1:1000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
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基因功能參考文獻：
- Autism spectrum disorder patient with the smallest inactivating deletion in the collybistin gene. PMID: 27238888
- Collybistin forms a complex with mTOR and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism. PMID: 25898924
- Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans. PMID: 25678704
- Data indicate that ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy. PMID: 21633362
- These results reveal that G(s) and G(q) signalings regulate hPEM-2 functions through PKA and c-Src in Neuro-2a neuroblastoma cells, respectively. PMID: 22033413
- major regulator of GABAergic postsynaptic gephyrin clustering PMID: 21807943
- Here we identified residues critical for interaction with gephyrin in the linker region between the SH3 and the DH domains of collybistin. PMID: 11727829
- translocates gephyrin to submembrane microaggregates; collybistin mutation (G55A)is found in exon 2 of the ARHGEF9 gene in a patient with clinical symptoms of both hyperekplexia and epilepsy PMID: 15215304
- Results show that hPEM-2 is a target protein of Smurf1. PMID: 18208356
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相關(guān)疾病：Epileptic encephalopathy, early infantile, 8 (EIEE8)
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亞細胞定位：Cytoplasm. Cell junction, synapse, postsynaptic density.
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組織特異性：Detected in brain. Detected at low levels in heart.
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數(shù)據(jù)庫鏈接：
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