Recombinant Human Protein unc-50 homolog (UNC50), partial

中文名稱：

人UNC50重組蛋白
貨號：

CSB-YP687496HU1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人UNC50重組蛋白
貨號：

CSB-EP687496HU1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人UNC50重組蛋白
貨號：

CSB-EP687496HU1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人UNC50重組蛋白
貨號：

CSB-BP687496HU1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人UNC50重組蛋白
貨號：

CSB-MP687496HU1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

UNC50
Uniprot No.：

Q53HI1
別名：

UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
基因功能參考文獻：
1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
亞細胞定位：

Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Unc-50 family
組織特異性：

Present in periodontal ligament fibroblasts (at protein level).
數據庫鏈接：

HGNC: 16046

OMIM: 617826

KEGG: hsa:25972

STRING: 9606.ENSP00000350409

UniGene: Hs.13370