UNC50 Antibody, Biotin conjugated

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) UNC50 Polyclonal antibody
Uniprot No.：

Q53HI1
基因名：

UNC50
別名：

UNC50; UNCL; HSD-23; HSD23; Protein unc-50 homolog; Periodontal ligament-specific protein 22; PDLs22; Protein GMH1 homolog; hGMH1; Uncoordinated-like protein
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Protein unc-50 homolog protein (15-82AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in the cell surface expression of neuronal nicotinic receptors. Binds RNA.
基因功能參考文獻(xiàn)：
1. Data indicate that biallelic mutation in the UNC50 gene underlies AMC through a probable loss of AChR expression at the neuromuscular junction which is essential for the cholinergic transmission during human muscle development. PMID: 29016857
2. depletion of UNC50 blocked early endosome-to-Golgi trafficking and induced lysosomal degradation of STx2. UNC50 acted by recruiting GBF1, an ADP ribosylation factor-guanine nucleotide exchange factor (ARF-GEF), to the Golgi. PMID: 28883040
3. UNC50 may plays some roles in HCC progression by affecting the EGFR pathway PMID: 25738771
4. UNCL plays important roles in the development, differentiation, and maintenance of periodontal tissues and in the mechanotransduction of periodontal ligament fibroblasts. PMID: 17004066
亞細(xì)胞定位：

Nucleus inner membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Unc-50 family
組織特異性：

Present in periodontal ligament fibroblasts (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 16046

OMIM: 617826

KEGG: hsa:25972

STRING: 9606.ENSP00000350409

UniGene: Hs.13370

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