Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial (ADHFE1), partial

中文名稱：

Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial(ADHFE1) ,partial
貨號：

CSB-YP811615HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial(ADHFE1) ,partial
貨號：

CSB-EP811615HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial(ADHFE1) ,partial
貨號：

CSB-EP811615HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial(ADHFE1) ,partial
貨號：

CSB-BP811615HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human Hydroxyacid-oxoacid transhydrogenase, mitochondrial(ADHFE1) ,partial
貨號：

CSB-MP811615HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

ADHFE1
Uniprot No.：

Q8IWW8
別名：

ADH8; ADHFE 1; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; Alcohol dehydrogenase; iron containing; 1; Fe containing alcohol dehydrogenase; Fe-containing alcohol dehydrogenase; HOT; HOT_HUMAN; Hydroxyacid oxoacid transhydrogenase; mitochondrial; Hydroxyacid-oxoacid transhydrogenase; mitochondrial
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
表達(dá)區(qū)域：

-
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
基因功能參考文獻(xiàn)：
1. These results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-mediated down expression of ADHFE1 and proliferation of CRC cells. PMID: 24886599
2. ADHFE1 has an important role of differentiation in CRC, as well as normal colorectal mucosa and embryonic developmental processes. PMID: 23517143
3. cloned and characterized an iron-activated alcohol dehydrogenase gene, Fe-containing alcohol dehydrogenase 1 (ADHFe1) PMID: 12592711
4. show that the ADHFe1 gene is related to bacterial GHB dehydrogenases and has a conserved NAD-binding site PMID: 19013439
亞細(xì)胞定位：

Mitochondrion.
蛋白家族：

Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
組織特異性：

Only expressed in adult liver.
數(shù)據(jù)庫鏈接：

HGNC: 16354

OMIM: 611083

KEGG: hsa:137872

STRING: 9606.ENSP00000379865

UniGene: Hs.720023