ADHFE1 Antibody

說明書

產品詳情

Uniprot No.：

Q8IWW8
基因名：

ADHFE1
別名：

ADH8 antibody; ADHFE 1 antibody; ADHFe1 antibody; Alcohol dehydrogenase iron-containing protein 1 antibody; Alcohol dehydrogenase; iron containing; 1 antibody; Fe containing alcohol dehydrogenase antibody; Fe-containing alcohol dehydrogenase antibody; HOT antibody; HOT_HUMAN antibody; Hydroxyacid oxoacid transhydrogenase; mitochondrial antibody; Hydroxyacid-oxoacid transhydrogenase antibody; mitochondrial antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human ADHFE1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
基因功能參考文獻：
1. These results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-mediated down expression of ADHFE1 and proliferation of CRC cells. PMID: 24886599
2. ADHFE1 has an important role of differentiation in CRC, as well as normal colorectal mucosa and embryonic developmental processes. PMID: 23517143
3. cloned and characterized an iron-activated alcohol dehydrogenase gene, Fe-containing alcohol dehydrogenase 1 (ADHFe1) PMID: 12592711
4. show that the ADHFe1 gene is related to bacterial GHB dehydrogenases and has a conserved NAD-binding site PMID: 19013439
亞細胞定位：

Mitochondrion.
蛋白家族：

Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
組織特異性：

Only expressed in adult liver.
數據庫鏈接：

HGNC: 16354

OMIM: 611083

KEGG: hsa:137872

STRING: 9606.ENSP00000379865

UniGene: Hs.720023

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