Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta (AKAP7)

中文名稱：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta(AKAP7)
貨號：

CSB-YP001529HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta(AKAP7)
貨號：

CSB-EP001529HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta(AKAP7)
貨號：

CSB-EP001529HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta(AKAP7)
貨號：

CSB-BP001529HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta(AKAP7)
貨號：

CSB-MP001529HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

AKAP7
Uniprot No.：

O43687
別名：

A kinase (PRKA) anchor protein 7; A kinase anchor protein 18 kD; A kinase anchor protein 7; A kinase anchor protein 7 isoform alpha; A kinase anchor protein 7 isoform beta; A kinase anchor protein 7 isoform gamma; A kinase anchor protein 7 isoforms alpha and beta; A kinase anchor protein 9 kDa; A kinase anchoring protein 18; A-kinase anchor protein 18 kDa; A-kinase anchor protein 7 isoforms alpha and beta; AKA7A_HUMAN; AKAP 18; AKAP 7; AKAP-7 isoforms alpha and beta; AKAP15; AKAP18; Akap7; HGNC377; OTTHUMP00000040266; Protein kinase A anchoring protein 7; Protein kinase A anchoring protein 7 isoform alpha; Protein kinase A anchoring protein 7 isoform beta; Protein kinase A anchoring protein 7 isoform gamma; Protein kinase A anchoring protein 7 isoforms alpha/beta; Protein kinase A-anchoring protein 7 isoforms alpha/beta
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-104
氨基酸序列

GQLCCFPFS RDEGKISELE SSSSAVLQRY SKDIPSWSSG EKNGGEPDDA ELVRLSKRLV ENAVLKAVQQ YLEETQNKNK PGEGSSVKTE AADQNGNDNE NNRK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
基因功能參考文獻：
1. AKAP7 expression levels may have clinical utility as a prognostic biomarker for post-stroke blood brain complications PMID: 28446746
2. Malonate in the nucleotide-binding site traps human AKAP18-gamma in a novel conformational state. PMID: 27487922
3. PKC tethered to AKAP7alpha was less susceptible to inhibition from the ATP-competitive inhibitor Go6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C. PMID: 24302730
4. Data from studies using recombinant proteins suggest that both AKAP7-gamma and AKAP7-alpha exhibit high-affinity interactions with isoenzymes of PKC (protein kinase C); AKAP7 could dictate PKC localization/function. PMID: 22670899
5. AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes PMID: 12804576
6. AKAP15 regulates ENaC via a novel PKA-independent pathway PMID: 17244820
7. AKAP18 contains a phosphodiesterase domain that binds AMP. PMID: 18082768
顯示更多

收起更多
亞細胞定位：

[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
組織特異性：

Expressed in brain, heart, lung, pancreas and skeletal muscle.
數據庫鏈接：

HGNC: 377

OMIM: 604693

UniGene: Hs.486483