AKAP7 Antibody

中文名稱：

AKAP7兔多克隆抗體
貨號：

CSB-PA001529LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA001529LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA001529LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA001529LA01HU at 1:120,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AKAP7 Polyclonal antibody
Uniprot No.：

O43687
基因名：

AKAP7
別名：

A kinase (PRKA) anchor protein 7 antibody; A kinase anchor protein 18 kD antibody; A kinase anchor protein 7 antibody; A kinase anchor protein 7 isoform alpha antibody; A kinase anchor protein 7 isoform beta antibody; A kinase anchor protein 7 isoform gamma antibody; A kinase anchor protein 7 isoforms alpha and beta antibody; A kinase anchor protein 9 kDa antibody; A kinase anchoring protein 18 antibody; A-kinase anchor protein 18 kDa antibody; A-kinase anchor protein 7 isoforms alpha and beta antibody; AKA7A_HUMAN antibody; AKAP 18 antibody; AKAP 7 antibody; AKAP-7 isoforms alpha and beta antibody; AKAP15 antibody; AKAP18 antibody; Akap7 antibody; HGNC377 antibody; OTTHUMP00000040266 antibody; Protein kinase A anchoring protein 7 antibody; Protein kinase A anchoring protein 7 isoform alpha antibody; Protein kinase A anchoring protein 7 isoform beta antibody; Protein kinase A anchoring protein 7 isoform gamma antibody; Protein kinase A anchoring protein 7 isoforms alpha/beta antibody; Protein kinase A-anchoring protein 7 isoforms alpha/beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human A-kinase anchor protein 7 isoforms alpha and beta protein (1-81AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，AKAP7 Antibody (CSB-PA001529LA01HU)，的標記方式是Non-conjugated。對于AKAP7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA001529LB01HU	AKAP7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA001529LC01HU	AKAP7 Antibody, FITC conjugated
Biotin	CSB-PA001529LD01HU	AKAP7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC,IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
基因功能參考文獻：
1. AKAP7 expression levels may have clinical utility as a prognostic biomarker for post-stroke blood brain complications PMID: 28446746
2. Malonate in the nucleotide-binding site traps human AKAP18-gamma in a novel conformational state. PMID: 27487922
3. PKC tethered to AKAP7alpha was less susceptible to inhibition from the ATP-competitive inhibitor Go6976 and the substrate-competitive inhibitor PKC 20-28, but not the activation-competitive inhibitor calphostin C. PMID: 24302730
4. Data from studies using recombinant proteins suggest that both AKAP7-gamma and AKAP7-alpha exhibit high-affinity interactions with isoenzymes of PKC (protein kinase C); AKAP7 could dictate PKC localization/function. PMID: 22670899
5. AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes PMID: 12804576
6. AKAP15 regulates ENaC via a novel PKA-independent pathway PMID: 17244820
7. AKAP18 contains a phosphodiesterase domain that binds AMP. PMID: 18082768
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亞細胞定位：

[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
組織特異性：

Expressed in brain, heart, lung, pancreas and skeletal muscle.
數據庫鏈接：

HGNC: 377

OMIM: 604693

UniGene: Hs.486483

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