GPX1 Recombinant Monoclonal Antibody

說明書

中文名稱：

GPX1重組抗體
貨號：

CSB-RA009866A0HU
規格：

￥1320
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA009866A0HU GPX1重組單克隆抗體是針對谷胱甘肽過氧化物酶1（GPX1）靶點開發的高特異性科研試劑。GPX1作為細胞內重要的抗氧化酶，通過催化還原型谷胱甘肽對過氧化物的清除反應，在維持氧化還原穩態、抵御自由基損傷中發揮核心作用，其表達水平與氧化應激相關疾病機制研究密切相關。本產品采用重組表達技術制備，經ELISA平臺嚴格驗證，展現出優異的抗原結合能力與信號特異性，可精準識別天然及重組GPX1蛋白。作為單克隆抗體，其具備高批次間一致性和穩定性，適用于細胞或組織樣本中GPX1蛋白的定量檢測、抗氧化通路的功能研究，以及體外模型中酶活性調控機制的探索。該抗體可廣泛應用于神經退行性疾病、代謝綜合征等病理過程中氧化損傷機制的解析，或在藥物開發中用于篩選調節GPX1活性的化合物。其穩定性和可重復性為相關領域的實驗設計提供了可靠工具，特別適用于需要高靈敏度檢測的體外研究場景。
Uniprot No.：

P07203
基因名：

GPX1
別名：

AL033363 antibody; Cellular glutathione peroxidase antibody; Glutathione peroxidase 1 antibody; Glutathione peroxidase antibody; GPx 1 antibody; GPx-1 antibody; GPX1 antibody; GPX1_HUMAN antibody; GPXD antibody; GSHPx-1 antibody; GSHPX1 antibody; MGC14399 antibody; MGC88245 antibody
反應種屬：

Human
免疫原：

A synthesized peptide derived from human GPX1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

Rabbit IgG
純化方式：

Affinity-chromatography
克隆號：

3G1
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Protects the hemoglobin in erythrocytes from oxidative breakdown. In platelets, plays a crucial role of glutathione peroxidase in the arachidonic acid metabolism.
基因功能參考文獻：
1. that polymorphisms in GPX1 and GPX4 are significantly associated with episodic memory and AD in a South Brazilian population PMID: 29246792
2. there is no correlation between idiopathic male infertility and the GPx1 codon Pro198Leu polymorphism; further studies are needed to investigate other genetic factors that influence the development of idiopathic male infertility PMID: 27028814
3. Increased glutathione peroxidase (GPx) activity seemed to compensate for a decrease in GPx1 protein due to enhanced degradation via the proteasome. Mass spectrometry analysis identified Lys-114 as a possible carbonylation target which provides a vestibule for the substrate H2O2 and thus enhances the enzymatic reaction PMID: 29499564
4. ESR1 and GPX1 expression levels were found to be significantly down-regulated by 14.7% and 7.4% (respectively) in the tumorous breast tissue when compared to the non-malignant one. PMID: 29543921
5. The result of this study suggested that GPX1 Pro198Leu polymorphism could not be a risk factor for breast cancer in Rwanda. PMID: 29411539
6. A significant increase in the T allele and TT genotype frequencies was observed in diabetic peripheral neuropathy patients compared to control diabetics. The association remained significant after correction for age, disease duration, HbA1c and BMI. PMID: 27592002
7. No significant differences in allelic or genotypic frequencies of GPX1 rs1050450 or GSTP1 rs1695 were detected between Chinese schizophrenia cases and controls. PMID: 28872562
8. Genetic variations in selenoprotein genes modulated both GPX1 and SELENOP selenoprotein gene expression and global gene expression in response to Brazil nut supplementation. PMID: 28696394
9. Allele-specific interaction between GPX1 and MnSOD affects the levels of Bcl2, Sirt3 and E-cadherin. PMID: 28587495
10. GPX1, GPX3 and GPX4 may be upregulated in response to a change in oxidative stress during an acute coronary syndromes PMID: 28298473
11. The Pro198Leu polymorphism (rs1050450) to the selenoprotein glutathione peroxidase 1 gene (GPX1), and GSTM1 deletion had no effect on mercury levels in mildly exposed people, suggesting these genetic variants impact mercury levels only in highly exposed populations. PMID: 27450956
12. Evaluation of Glutathione Peroxidase and KCNJ11 Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation PMID: 28073131
13. G/C (rs8179169; Arg5Pro) and T/C (rs4991448; Leu6Pro) polymorphisms significantly associated with vitiligo PMID: 26991090
14. Data show that the inflammation of the gallbladder wall (IGW) correlated significantly with plasma GPX1 and hs-CRP (high-sensitivity C-reactive protein) values suggesting that inflammation and oxidative stress are related. PMID: 29187474
15. High GPX1 expression is associated with oral squamous cell carcinoma. PMID: 28653098
16. GPX1 is a gatekeeper restraining the oncogenic power of mitochondrial ROS generated by SOD2 is presented. Review. PMID: 28087256
17. Using lens epithelial cells derived from targeted inactivation of Prdx6(-/-) gene and relative enzymatic and stability assays, we discovered dramatic increases in GSH-peroxidase (30%) and aiPLA2 (37%) activities and stability in the K122/142 R mutant, suggesting Sumo1 destabilized Prdx6 integrity PMID: 28055018
18. Coronary angiography findings indicated that individuals possessing Pro198Leu (CT) polymorphism were found to be associated with low erythrocyte GPX-1 activity and increased susceptibility for coronary artery disease. PMID: 27229152
19. High GPX1 expression is associated with Thyroid Tumors. PMID: 26970173
20. Data suggest that serum myeloperoxidase (GPX1) levels are significantly associated with higher asymmetric dimethyl-arginine (ADMA) levels and up-regulation of circulating components of renin-angiotensin-aldosterone-system in patients with cardiovascular disease (CVD). Serum levels of ADMA and angiotensin II are more predictive for all-cause and CVD mortality compared to GPX1. PMID: 28322753
21. Pro198Leu of GPX1 might be a genetic risk factor in the development of Nephrolithiasis in South Iranian patients with lower Glutathione Peroxidase enzyme activity. PMID: 28174350
22. our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population. PMID: 28547970
23. GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke PMID: 28070146
24. Knockdown of GPX1 in hucMSCs abrogated antioxidant and anti-apoptotic abilities of hucMSC-Ex and diminished the hepatoprotective effects of hucMSC-Ex in vitro and in vivo. Thus, hucMSC-Ex promote the recovery of hepatic oxidant injury through the delivery of GPX1. PMID: 28089078
25. The potential protective effect without statistical relationships were also observed for other genotypes and alleles studied polymorphic variants of antioxidant enzymes in CD and CAT- 262C / T and + 35 A / C SOD1 in UC. Conducted our audit should be extended to more group of patients in order to assess whether or not to confirm the observed during analysis, the protective effect of CAT-262 C / T in ulcerative colitis and PMID: 28141554
26. No significant differences in SOD and GPx activity both in plasma and saliva were found between Crohn's Disease remission group and the control group. PMID: 28011951
27. GPX1 and SEPP1 Single Nucleotide Polymorphism were not associated with any changes in the expression of related genes. GPX1 was shown to modulate the expression of unrelated target, SEP15, upon Se supplementation, both alone and in combination with SEPP1. PMID: 26658762
28. Study demonstrates that SOD2 rs4880, GPX1 rs1050450 and CAT rs1001179 are not associated with an increased susceptibility to epilepsy after neonatal hypoxic-ischemic encephalopathyor its drug resistance PMID: 28222320
29. Data show that antioxidant enzymes SOD2 and GPX1 expression and GPX1 and SOD1 activity were significantly higher in patients at diagnosis of bladder cancer (BC) in comparison to controls. PMID: 28179340
30. Data show that the placement of rectus sheath block (RSB) analgesia did not significantly affect the level of oxidative stress biomarker plasma glutathione peroxidase (GPX1) level in patients with benign disease or cancer. PMID: 28179349
31. Adiponectin gene promoter -11377C/G (CG), -11377C/G (GG), GPx-1 gene C594T (CT), C594T (TT), and cigarette smoking are risk factors in nonalcoholic fatty liver disease (NAFLD). PMID: 26897098
32. Our results suggest that GSTP1 rs1695 and GPX1 rs1050450 single nucleotide polymorphisms have no effect on the risk of preeclampsia in the Chinese Han population. PMID: 27825163
33. Results show no significant association between glutathione peroxidase 1 (GPX1) Pro198Leu polymorphism and risk of bladder cancer. PMID: 28145855
34. It was concluded that the genotype for SNPs in GPX1 and gender affected biomarkers of Se status in this pilot study with healthy Brazilians. PMID: 27164132
35. The effects of oleuropein (OL) on hydrogen peroxide-induced oxidative stress in L02 cells showed that SOD1, GPx1, and catalase levels were all increased, and suggested that OL is a potent antioxidant and may be therapeutically useful in liver disease prevention. PMID: 27914828
36. This meta-analysis showed a significant association between low GPx level and vitiligo. PMID: 27218102
37. GPx-1 Pro200Leu polymorphism was associated with obesity especially with morbid obesity, but not with obese participants with prediabetes or diabetes PMID: 26545512
38. variants of GPx1 and MnSOD should not be considered as a risk factor of laryngeal squamous cell carcinoma. PMID: 27188866
39. Glucose oscillations may exert more deleterious effects on the endothelium than high glucose, likely due to an impaired response of glutathione peroxidase-1, coupled by the upregulation of miR-185 PMID: 27137793
40. Results showed no statistically significant difference between the vitiligo and MnSOD Ala-9Val and GPx1 Pro198Leu gene polymorphisms in Turkish population. PMID: 27100222
41. The purpose of the study was to evaluate the plasma level of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) and the association between polymorphic variants in genes encoding for GPx1, SOD, CAT and the risk of distal symmetric polyneuropathy in type 2 diabetes mellitus patients. PMID: 26674569
42. This study examined the relationship between levels of GPx activity, reactive oxygen species, and platelet activation in 51 acute coronary syndrome (ACS) patients. PMID: 27993878
43. The MnSOD, GPX1 and CAT genotypes and allele frequencies of acute kidney injury patients did not differ significantly from those of healthy controls. PMID: 26787049
44. the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing acute myeloid leukemia PMID: 26823947
45. GPX1 Pro198Leu rs1050450 genotypes differentially affect the selenium status and GPx activity. PMID: 26661784
46. patients with end-stage renal disease (ESRD) and those without chronic kidney disease (CKD) of Han Chinese origin, with SOD2 (Val16Ala), GPX1 (Pro197Leu), and PPAR-gamma (Pro12Ala, C161T) were genotyped. PMID: 26881045
47. 1,25D3 works as a modifier of NF-kappaB/GPX1/uPA expression, inhibiting cisplatin-resistance and cell invasive ability of salivary adenoid cystic carcinoma cells PMID: 26782341
48. SOD2 but not GPx1 activity decreased significantly in the presence of the mutated allele (Val and Leu, respectively). PMID: 27067415
49. GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients PMID: 26662676
50. An increase in both SOD1 and GPx1 activity is involved in the protective effect of sulodexide on ischemic endothelial cells. PMID: 26477504
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亞細胞定位：

Cytoplasm.
蛋白家族：

Glutathione peroxidase family
組織特異性：

Expressed in platelets (at protein level).
數據庫鏈接：

HGNC: 4553

OMIM: 138320

KEGG: hsa:2876

STRING: 9606.ENSP00000407375

UniGene: Hs.76686

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