SLC39A6 monoclonal antibody

說明書

中文名稱：

SLC39A6重組抗體
貨號：

CSB-RA621669MA1HU
規格：

￥1320
圖片：
The Binding Activity of SLC39A6 with anti-SLC39A6 antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC39A6(CSB-BP621669HU) at 1 μg/ml can bind Anti-SLC39A6-1 recombinant antibody, the EC₅₀ is 0.6873-0.9010 ng/mL.

The Binding Activity of Cynomolgus SLC39A6 with Anti-SLC39A6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus SLC39A6 (CSB-BP5043MOV) at 2 μg/mL can bind Anti-SLC39A6 recombinant antibody. The EC₅₀ is 0.8290-0.9864 ng/mL.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CSB-RA621669MA1HU SLC39A6重組單克隆抗體是針對鋅轉運蛋白家族成員SLC39A6/ZIP6開發的高特異性科研試劑。該蛋白作為跨膜鋅離子轉運體，參與調控細胞內鋅離子穩態，在細胞增殖、分化及腫瘤發生發展中具有潛在調控作用。本產品經ELISA平臺嚴格驗證，展現出優異的抗原結合能力與檢測靈敏度，其重組單克隆抗體特性確保批次間高度一致性，滿足定量分析與重復性實驗需求。該抗體適用于基礎科研中探索SLC39A6在腫瘤微環境、上皮間質轉化（EMT）等生理病理過程中的分子機制，可配合體外培養細胞模型或組織樣本進行蛋白表達水平分析，為鋅代謝相關信號通路研究提供可靠工具。建議配合陽性對照樣本以優化實驗條件，適用于細胞裂解液、重組蛋白等樣本類型的檢測需求。
Uniprot No.：

Q13433
基因名：

SLC39A6
別名：

SLC39A6 monoclonal antibody
反應種屬：

Human, Macaca fascicularis
免疫原：

Recombinant Human SLC39A6 protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

hIgG1
純化方式：

Affinity-chromatography
克隆號：

13F1
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May act as a zinc-influx transporter.
基因功能參考文獻：
1. ZIP6 deficiency disturbs intracellular Zn2+ homeostasis, leading to increased cell survival in hypoxia and reduced E-cadherin expression, indicating that decreased ZIP6 expression is strongly associated with resistance to hypoxia. PMID: 28833062
2. SLC39A6 promotes aggressiveness of esophageal carcinoma cells by increasing intracellular levels of zinc, activating phosphatidylinositol 3-kinase signaling, and up-regulating genes that regulate metastasis. PMID: 28209530
3. Upregulation of SLC39A6 is associated with hepatocellular carcinoma. PMID: 26684241
4. SLC39A6 may have a tumor promoting role in esophageal carcinoma PMID: 26444413
5. Knock-down of ZIP6 but not ZIP7 in MIN6 beta cells impaired the protective effects of GLP-1 on fatty acid-induced cell apoptosis, possibly via reduced activation of the p-ERK pathway PMID: 25969539
6. drug resistance of ovarian cancer cells to trichostatin A may be related to expression of the LIV1 gene PMID: 25420545
7. Zinc and its transporters, ZIP6 and ZIP10, are required for the breast cancer cells motility stimulated with high glucose level, such as in diabetes. PMID: 24587242
8. a causative role for ZIP6 in cell motility and migration PMID: 23919497
9. Down-regulated LIV-1 cells showed significant inhibition of proliferation in vitro and reduction of tumor growth in vivo. Furthermore, E-cadherin expression increased in LIV-1 siRNA expressing Hep-G2. PMID: 23437163
10. SLC39A6 has an important role in the prognosis of esophageal squamous-cell carcinoma and may be a potential therapeutic target. PMID: 23644492
11. Some studies correlate LIV-1 expression with a more aggressive cancer phenotype and increased likelihood for metastasis to lymph nodes. In contrast, other evidence suggests this transporter is associated with a more favorable prognosis. [review] PMID: 22852056
12. The results of this study showed evidence for a positive correlation between LIV1 and ZnT6 insuperior temporal, occipital, and frontal gyri in patient with alzheimer disease. PMID: 22349685
13. LIV-1 is involved in prostate cancer progression as an intracellular target of growth factor receptor signaling which promoted EMT and cancer metastasis PMID: 22110740
14. LIV-1 mRNA upregulation is associated with the progression of cervical cancer but not with the development of endometrial carcinoma. PMID: 17959546
15. The present study identifies LIV1 as a critical mediator responsible for HDACi-induced apoptosis. The effect of LIV1 is, at least in part, mediated by affecting intracellular zinc homeostasis. PMID: 19887557
16. Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role. PMID: 19852955
17. Structure-function analysis of LIV-1. PMID: 12839489
18. data suggest that LIV-1 protein is a promising candidate for a novel marker for breast cancer patients with better outcome PMID: 15986450
19. regulation of LIV-1 protein in human breast cancer xenografts PMID: 17786585
20. Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression. PMID: 17825787
21. LIV-1 may be a regulator of E-cadherin PMID: 18330719
22. Single nucleotide polymorphism in SLC39A6 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
23. LIV-1 enhances the aggressive phenotype through the induction of epithelial to mesenchymal transition in human pancreatic carcinoma cells. PMID: 19724917
24. LIV-1 co-clusters with estrogen receptor alpha in microarray analysis of breast cancer biopsies. PMID: 11911440
25. Review of LIV-1 and other LZT proteins. PMID: 12659941
26. LIV-1, a member of the ZIP family of zinc transporters, is an integral plasma membrane protein that transports zinc into cells. PMID: 12839489
27. LIV-1 is coregulated with estrogen receptor in some breast cancers. PMID: 12960427
顯示更多

收起更多
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

ZIP transporter (TC 2.A.5) family
組織特異性：

Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
數據庫鏈接：

HGNC: 18607

OMIM: 608731

KEGG: hsa:25800

STRING: 9606.ENSP00000269187

UniGene: Hs.79136

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human