MRAS Recombinant Monoclonal Antibody
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中文名稱：MRAS重組抗體
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貨號：CSB-RA158563A0HU
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規格：￥1320
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圖片：
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Western Blot
Positive WB detected in: MCF-7 whole cell lysate, PC3 whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, HEK293 whole cell lysate
All lanes: MRAS antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 24, 16 kDa
Observed band size: 24 kDa
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其他：
產品詳情
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產品描述：MRAS Recombinant Monoclonal Antibody（CSB-RA158563A0HU）是針對MRAS蛋白開發的高特異性抗體，靶向RAS家族中參與細胞信號轉導調控的關鍵成員MRAS。該蛋白通過介導RAS/MAPK信號通路調控細胞增殖、分化與存活，其異常表達與多種腫瘤發生及轉移密切相關。本抗體采用重組表達技術制備，經嚴格驗證可在Western Blot（WB）實驗中穩定識別天然及重組MRAS蛋白，推薦使用稀釋比為1:500-1:2000，實驗結果顯示特異性結合且背景干擾低，同時適用于ELISA平臺對目標蛋白的定量檢測。該產品為科研領域提供可靠工具，可應用于腫瘤發生機制研究、MAPK信號通路調控分析、體外細胞模型功能驗證等場景，尤其適用于探索MRAS在癌癥生物學中的功能及其與其他RAS家族蛋白的相互作用研究，為靶向治療開發提供基礎實驗支持。
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Uniprot No.：
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基因名：
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別名：Ras-related protein M-Ras (Ras-related protein R-Ras3), MRAS, RRAS3
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反應種屬：Human
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免疫原：A synthesized peptide derived from human MRAS
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：Rabbit IgG
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純化方式：Affinity-chromatography
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克隆號：18E11
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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產品提供形式：Liquid
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應用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway.
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基因功能參考文獻：
- acute coronary syndrome in Czechs (30.4% vs 29.4% carriers of the minor T allele of MRAS[recessive model], p = 0.54; OR 1.05; 95% CI 0.89-1.24 for males and 32.1% vs 29.7% carriers of the minor T allele, p = 0.28; OR 1.12; 95% CI 0.91-1.37 for females) PMID: 29264877
- Results discovered for the first time that MRAS is recurrently mutated, indicating that MRAS mutations could drive tumorigenesis of Type IV gastric neoplasm. PMID: 27891760
- The association of the MARS rs6782181 polymorphism and serum lipid levels is different between the Mulao and Han populations, or between males and females in the both ethnic groups. PMID: 25973078
- The MRAS gene loci might have a minor effect in conferring susceptibility to coronary artery disease in the Chinese population. PMID: 25800439
- Both MRAS and SHOC2 play a key role in polarized migration. PMID: 24211266
- implicated in a novel pathway of neuronal differentiation by coupling specific trophic factors to the MAPK cascade through the activation of B-Raf PMID: 12138204
- These findings proved a crucial role of the cross-talk between two Ras-family GTPases M-Ras and Rap1, mediated by RA-GEF-2, in adhesion signaling. PMID: 17538012
- Identification of one new CAD risk locus on 3q22.3 in MRAS, and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43. PMID: 19198612
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亞細胞定位：Cell membrane; Lipid-anchor; Cytoplasmic side.
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蛋白家族：Small GTPase superfamily, Ras family
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組織特異性：Expression highly restricted to the brain and heart.
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數據庫鏈接：
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