IL1RAP Recombinant Monoclonal Antibody
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中文名稱：IL1RAP Recombinant Monoclonal Antibody
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貨號(hào)：CSB-RA878844MA2HU
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規(guī)格：￥1320
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圖片：
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The Binding Activity of Mouse Il1rap with Anti-IL1RAP recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Il1rap protein (CSB-MP730751MO) at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 2.279-3.955 ng/mL. -
The Binding Activity of Rat Il1rap with Anti-IL1RAP recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Il1rap protein (CSB-MP733954RA) at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 3.180-4.082 ng/mL.
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：C3orf13 antibody; FLJ37788 antibody; IL 1 receptor accessory protein antibody; IL 1R 3 antibody; IL 1R3 antibody; IL 1RAcP antibody; IL 1RAP antibody; IL-1 receptor accessory protein antibody; IL-1R-3 antibody; IL-1R3 antibody; IL-1RAcP antibody; IL-1RAP antibody; IL1 receptor accessory protein antibody; IL1AP_HUMAN antibody; IL1R3 antibody; IL1RAcP antibody; Il1rap antibody; Interleukin 1 Accessory Protein antibody; interleukin 1 receptor 3 antibody; Interleukin 1 receptor accessory protein antibody; interleukin 1 receptor accessory protein beta antibody; Interleukin-1 receptor 3 antibody; Interleukin-1 receptor accessory protein antibody
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反應(yīng)種屬：Mouse, Rat
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免疫原：Recombinant Human IL1RAP protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Monoclonal
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抗體亞型：mIgG2a
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純化方式：Affinity-chromatography
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克隆號(hào)：10D6
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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推薦稀釋比：
Application Recommended Dilution ELISA 1:5000-1:50000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).; Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.; Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
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基因功能參考文獻(xiàn)：
- Expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas PMID: 29238884
- These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. PMID: 27621309
- single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
- The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework. PMID: 26268530
- The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk. PMID: 25517029
- Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis. PMID: 24935223
- Plasma sIL1RAP levels are reduced in obesity and can potentially act as biomarkers of obesity. PMID: 24915116
- Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution. PMID: 23980170
- Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells. PMID: 22723552
- Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. PMID: 22778412
- decreased protein levels in the peritoneal fluid of women with endometriosis PMID: 21958553
- Studies indicate that new targets have recently been investigated as potential modulators in myeloid leukemia pathogenesis, including miR-328, BMI1, FOXOs and IL1RAP. PMID: 21373837
- This study showed a significant downregulation of soluble interleukin-1 receptor accessory protein expression in the endometrium of women with endometriosis. PMID: 21272866
- identifies IL1RAP as a unique cell surface biomarker distinguishing Ph(+) from Ph(-) candidate chronic myeloid leukemia (CML) stem cells and opens up a previously unexplored avenue for therapy of CML PMID: 20805474
- Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling PMID: 11880380
- soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor PMID: 12530978
- The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation. PMID: 12781872
- IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP in Jurkat cells PMID: 14734551
- Specific destabilization of membrane-bound IL-1 receptor accessory protein mRNA in HepG2 hepatoma cells is mediated by its 2.8-kilobase 3'-untranslated region. PMID: 15528363
- Analysis of a three-dimensional docking model of the TIR-TIR interaction between MyD88 and IL1RAcP PMID: 15849357
- IL-1ra is associated with preserved beta-cell capacity in type 1 diabetes. PMID: 18299313
- an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS. PMID: 19481478
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亞細(xì)胞定位：[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
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蛋白家族：Interleukin-1 receptor family
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組織特異性：Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia
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