kgp Antibody

^{Rare Species}

文獻引用 (1) 說明書

中文名稱：

kgp兔多克隆抗體
貨號：

CSB-PA464342LA01EXZ
規格：

￥440
圖片：
Western Blot
Positive WB detected in Recombinant protein
All lanes: kgp antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 56 kDa
Observed band size: 56 kDa
其他：

產品詳情
產品評價
引用文獻
相關產品
靶點詳情

產品詳情

產品描述：

The kgp antibody is designed to recognize the Porphyromonas gingivalis kgp protein. When a rabbit received an injection of the recombinant Porphyromonas gingivalis Lys-gingipain protein (229-594aa), an immune response occurred in the rabbit producing large amounts of antibodies against the kgp protein. The rabbit's blood was collected and isolated to get the anti-serum, which was purified by protein G to obtain the kgp polyclonal antibody (purity 95%⁺). This kgp antibody has accessed its specificity in ELISA and WB applications. Lys-gingipain is a Porphyromonas gingivalis-producing protease that plays a key role in viral pathogenicity.

Lys-gingipain can cleave a wide range of host proteins, including immunoglobulins, complement proteins, and extracellular matrix proteins such as collagen and elastin, enabling them to invade and destroy host tissues leading to tissue damage and inflammation. In addition to its proteolytic activity, Lys-gingipain also has been shown to inhibit the host immune response, allowing P. gingivalis to establish a persistent infection and cause chronic periodontitis.
產品名稱：

Rabbit anti-Porphyromonas gingivalis kgp Polyclonal antibody
Uniprot No.：

B2RLK2
基因名：

kgp
別名：

kgp antibody; PGN_1728Lys-gingipain antibody; EC 3.4.22.47 antibody; Lysine-specific cysteine proteinase Kgp) [Cleaved into: Lys-gingipain catalytic subunit; 39 kDa adhesin; 15 kDa adhesin; 44 kDa adhesin] antibody
宿主：

Rabbit
反應種屬：

Porphyromonas gingivalis
免疫原：

Recombinant Porphyromonas gingivalis Lys-gingipain protein (229-594AA)
免疫原種屬：

Porphyromonas gingivalis

標記方式：

Non-conjugated

本頁面中的產品，kgp Antibody (CSB-PA464342LA01EXZ)，的標記方式是Non-conjugated。對于kgp Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA464342LB01EXZ	kgp Antibody, HRP conjugated	ELISA
FITC	CSB-PA464342LC01EXZ	kgp Antibody, FITC conjugated
Biotin	CSB-PA464342LD01EXZ	kgp Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Interplay between Porphyromonas gingivalis Hemophore-Like Protein HmuY and Kgp/RgpA Gingipains Plays a Superior Role in Heme Supply M ?miga,Microbiology spectrum,2023

產品評價

靶點詳情

功能：

Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
基因功能參考文獻：
1. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
亞細胞定位：

[Lys-gingipain catalytic subunit]: Secreted.
蛋白家族：

Peptidase C25 family
數據庫鏈接：

KEGG: pgn:PGN_1728

STRING: 431947.PGN_1728

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