XRCC4 Antibody
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中文名稱：XRCC4兔多克隆抗體
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貨號：CSB-PA956465
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from COLO205 cells, using XRCC4 antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) XRCC4 Polyclonal antibody
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Uniprot No.：
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基因名：XRCC4
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthesized peptide derived from Internal of Human XRCC4.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：DNA non-homologous end joining (NHEJ) core factor, required for double-strand break repair and V(D)J recombination. Acts as a scaffold protein that regulates recruitment of other proteins to DNA double-strand breaks (DSBs). Associates with NHEJ1/XLF to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired. The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other. The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors. Plays a key role in the NHEJ ligation step of the broken DNA during DSB repair via direct interaction with DNA ligase IV (LIG4): the LIG4-XRCC4 subcomplex reseals the DNA breaks after the gap filling is completed. XRCC4 stabilizes LIG4, regulates its subcellular localization and enhances LIG4's joining activity. Binding of the LIG4-XRCC4 subcomplex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Promotes displacement of PNKP from processed strand break termini.; Acts as an activator of the phospholipid scramblase activity of XKR4. This form, which is generated upon caspase-3 (CASP3) cleavage, translocates into the cytoplasm and interacts with XKR4, thereby promoting phosphatidylserine scramblase activity of XKR4 and leading to phosphatidylserine exposure on apoptotic cell surface.
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基因功能參考文獻(xiàn)：
- These data imply that the level of XRCC4 expression could be used to predict the effects of apoptosis-inducing drugs in cancer treatment. PMID: 29233683
- Three-locus model of gene-gene interactions OGG1 (rs1052133) * ADPRT (rs1136410) * XRCC4 (rs6869366) was associated with high genotoxic risk in coal miners. PMID: 28992182
- Variant rs3734091 was found to be significantly associated with breast cancer while rs6869366 variant did not show any association. These SNPs may influence the susceptibility of individuals to breast cancer in this Indian population. PMID: 29452234
- Results showed that eNOS and XRCC4 VNTR variants might play a potential role in schizophrenia + nicotine dependence and/or nicotine dependence pathophysiology. PMID: 29050484
- Phospho-blocking and -mimicking mutations impact both the stability and DNA bridging capacity of XRCC4/XLF complexes, but without affecting their ability to stimulate LIG4 activity. Implicit in this finding is that phosphorylation may regulate DNA bridging by XRCC4/XLF filaments. PMID: 28500754
- This study demonstrated both ligase IV and XRCC4 may act in concert to modulate the development of glioma. PMID: 27508978
- Data suggest that genetic variants of XRCC4 and ERCC1 may independently or jointly affect survival in chemotherapy-treated gastric cancer (GCa) patients by modulating the gene expression in the tumors. PMID: 28796378
- In a recombinant PNKP-XRCC4-LigIV complex, stable binding of PNKP requires XRCC4 phosphorylation. Only one PNKP protomer binds per XRCC4 dimer. Both the PNKP FHA and catalytic domains contact the XRCC4 coiled-coil and LigIV BRCT repeats. Multipoint contacts between PNKP and XRCC4-LigIV regulate PNKP recruitment and activity within NHEJ. PMID: 28453785
- Data suggest that stimulation of Artemis nuclease/DCLRE1C activity by XRCC4-DNA ligase IV hetero-complex and efficiency of blunt-end ligation are determined by structural configurations at the DNA ends. (XRCC4 = X-ray repair cross complementing 4) PMID: 28696258
- the various XRCC4 mutations that lead to primordial dwarfism and their impact on non-homologous end joining and V(D)J recombination are discussed (Review) PMID: 27169690
- XRCC4 expression might have an influence on results of radiotherapy for patients with esophageal squamous cell carcinoma. PMID: 27338590
- uterine cervical cancer patients with high Ku86 and XRCC4 expression had a significantly lower 5-year metastasis-free rate than others. PMID: 26867665
- Frequencies of XRCC4-1394 T/G+G/G genotypes were higher in patients (%34) than the controls (%18.7). The statistical analysis revealed that the individuals who had XRCC4-1394 T/G+G/G genotype had an increased risk for autism spectrum disorder (OR = 2.23, 95% CI = 1.10-4.55) PMID: 27064873
- Genetic Variations in XRCC4 (rs1805377) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection. PMID: 26925648
- These results suggested potential usefulness of the phosphorylation status of XRCC4 Ser320 as an indicator of DNA-PK functionality in living cells. PMID: 26666690
- Association between insertion/deletion polymorphism in intron 3 of XRCC4 and susceptibility to type I bipolar disorder PMID: 26484731
- For XRCC4 (rs1805377) polymorphism, no difference was found in distribution between the ESCC and control groups. PMID: 26166223
- using dual- and quadruple-trap optical tweezers combined with fluorescence microscopy, we show how human XRCC4, XLF and XRCC4-XLF complexes interact with DNA in real time PMID: 27437582
- The ends are then closely aligned, which requires XLF, a non-catalytic function of XRCC4-LIG4, and DNA-PK activity PMID: 26990988
- Polymorphisms of XRCC4 are associated with susceptibility to Colorectal Cancer. PMID: 25662981
- FBXW7 facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 in tumor cells. PMID: 26774286
- The XRCC4 -1394T/G polymorphism is associated with susceptibility to endometriosis in an Iranian population. PMID: 26088159
- Our results suggest that the XRCC4 rs2075685 polymorphism could influence the susceptibility to pancreatic cancer in a Chinese population. PMID: 26345895
- The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition PMID: 26026052
- Point mutations in XRCC4 is associated with microcephaly, short stature and genomic instability. PMID: 25839420
- Genetic susceptibility to schizophrenia was found in patients with genetic polymorphisms in intron 3 of the XRCC4 gene. PMID: 26112447
- our results suggest that XRCC4 rs2075685 polymorphism plays an important role in the risk of pancreatic cancer in a Chinese population PMID: 26045837
- Nonsense mutations in human XRCC4 have recently been associated with primordial dwarfism and, in our cases, with adult-onset neurological impairment, suggesting an important role for DNA repair in the brain. PMID: 25872942
- Polymorphisms of insertion/deletion at the intron 3 of the XRCC4 is associated with gastric cancer. PMID: 25527410
- Variants of the DNA damage repair gene XRCC4 increase the risk of esophageal cancer PMID: 25612937
- no association was found between variants of XRCC4 rs2075685 and XRCC4 rs1805377 and development of glioma PMID: 25973104
- study identified a novel pathogenic variant in XRCC4; finding expands the spectrum of DNA damage repair syndromes to include XRCC4 deficiency causing severe postnatal growth failure, microcephaly, gonadal failure, metabolic syndrome, and possibly tumor predisposition PMID: 25742519
- Our data showed that Cd altered the phosphorylation of DNA-PKcs, and reduced the expression of both XRCC4 and Ligase IV in irradiated cells. PMID: 26201248
- our findings document the role of XRCC4 in non-BRCA1/2 breast cancer PMID: 25360583
- the intron 3 VNTR polymorphism in the XRCC4 gene may be associated with the etiopathogenesis of RA as a marker of immune aging. PMID: 25494482
- The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 and that the nuclear localizing ability is essential for DSB repair function of XRCC4. PMID: 25934149
- The XRCC4 promoter -652G>T polymorphism is functional and may influence genetic susceptibility to prostate cancer. PMID: 25096509
- We present comprehensive genetic and cellular evidence that mutations in XRCC4 cause microcephalic primordial dwarfism. PMID: 25728776
- XRCC4 C-terminal point mutants, R325F and N326L, are functionally deficient in terms of cell survival after irradiation. PMID: 25597996
- There was longer survival among patients with non-invasive tumours associated with DNA repair X-ray repair cross-complementing protein 4 (XRCC4) heterozygous genotype compared with wild-type. PMID: 24666523
- Phosphorylation of XRCC4 in mitosis was not responsible for its failure to localize to mitotic chromosomes and phosphorylation did not affect the interaction of XRCC4 with DNA ligase IV PMID: 25165869
- Taken together, our results indicate that XRCC4 is required not only for the promotion of NHEJ during interphase but also for its M-phase-specific suppression of DSB repair. PMID: 25166505
- XRCC4 codon 247 polymorphism may be associated with DIA risk and prognosis among the Guangxi population. PMID: 24378850
- Results show that in cells deficient for Lig4, chromosomal translocations junctions had significantly longer deletions and more microhomologies. PMID: 25201414
- Characterization of the protein interaction domains that modulate the XRCC4/Ligase IV interaction. PMID: 23794378
- Single nucleotide polymorphisms in XRCC4 were associated with breast cancer risk. PMID: 24062231
- These results indicate for the first time that DNA ligase IV (LIG4) rs1805388 and X-ray Repair Cross Complementing-4 (XRCC4) rs1805377, alone or in combination, are associated with a risk of gliomas. PMID: 23663450
- The induced DNA damage by Methyl Methanesulfonate increases in Chronic Obstructive Pulmonary Disease patients with variant genotypes in OGG1 (Ser326Cys) showing impairment of DNA repair. PMID: 24053728
- XRCC4P may be a genetic modifier for the risk and outcome of hepatocellular carcinoma induced by aflatoxin B1 exposure. PMID: 23788213
- The chromatin binding of XRCC4 was dependent on the presence of LIG4. PMID: 23994631
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相關(guān)疾病：Short stature, microcephaly, and endocrine dysfunction (SSMED)
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亞細(xì)胞定位：Nucleus. Chromosome.; [Protein XRCC4, C-terminus]: Cytoplasm.
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蛋白家族：XRCC4 family
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組織特異性：Widely expressed.
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