UMPS Antibody

中文名稱：

UMPS兔多克隆抗體
貨號：

CSB-PA728898LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA728898LA01HU diluted at 1:100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA728898LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of Hela cells with CSB-PA728898LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) UMPS Polyclonal antibody
Uniprot No.：

P11172
基因名：

UMPS
別名：

ODC antibody; OMPdecase antibody; OPRT antibody; OPRTase antibody; Orotate phosphoribosyl transferase and orotidine 5' decarboxylase antibody; Orotate phosphoribosyltransferase antibody; Orotate phosphoribosyltransferase phosphoribosyltransferase antibody; Orotidine 5' phosphate decarboxylase antibody; Orotidine 5''-phosphate decarboxylase antibody; RP11-71H17.9 antibody; UMP synthase antibody; Umps antibody; UMPS_HUMAN antibody; Uridine 5' monophosphate synthase antibody; Uridine monophosphate synthetase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Uridine 5\'-monophosphate synthase protein (314-444AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，UMPS Antibody (CSB-PA728898LA01HU)，的標記方式是Non-conjugated。對于UMPS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA728898LB01HU	UMPS Antibody, HRP conjugated	ELISA
FITC	CSB-PA728898LC01HU	UMPS Antibody, FITC conjugated
Biotin	CSB-PA728898LD01HU	UMPS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria. PMID: 28205048
2. The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer PMID: 28347333
3. OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. PMID: 24158442
4. The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer PMID: 22249354
5. [review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity PMID: 19562503
6. OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU. PMID: 22931617
7. Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS. PMID: 21631301
8. novel phosphoribosyltransferase transition states PMID: 20527751
9. orotate phosphoribosyl transferase/DPD ratio has a relation to cancer staging and survival rate. PMID: 20647710
10. Increased orotate phosphoribosyltransferase expression is associated with bladder cancers. PMID: 20112501
11. expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer PMID: 14562021
12. thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia PMID: 15999119
13. orotate phosphoribosyl transferase has a role in lymph node metastasis of gastric cancer PMID: 16142362
14. The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity. PMID: 16328050
15. The OPRT Gly213Ala polymorphism seems to be a useful marker for predicting toxicity to bolus 5-FU chemotherapy. PMID: 16818689
16. Overexpression of the OPRT gene plays an important role in the antiproliferative effect of 5-FU. PMID: 17237621
17. High expression of OPRT is associated with the response to adjuvant chemotherapy in human pancreatic cancer PMID: 17549346
18. data suggest that OPRT is involved in early events of pancreatic and gallbladder carcinogenesis and invasion of hepatocellular carcinomas PMID: 17607371
19. decreased the sensitivities of the cultured tumor cells to 5-FU. These results suggest that the OPRT expression level in tumors is an additional determinant of the efficacy of 5-FU. PMID: 17854773
20. OPRT activity levels in tumor tissue may be prognostic factor for survival in colorectal carcinoma with radical resection and 5-FU chemotherapy;postoperative survival was significantly better in patients with high OPRT activity PMID: 18597678
21. determination of OPRT levels in gastric carcinoma tissue enables to predict the response to S-1-based neoadjuvant/adjuvant chemotherapy PMID: 18633253
22. orotate phosphoribosyltransferase is involved in the invasion and metastasis of colorectal carcinoma PMID: 18949394
23. decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-FU PMID: 19020740
24. head & neck, gastric, colorectal, breast, lung & pancreatic cancer were examined; findings show mRNA expression & protein level of thymidylate synthase, dihydropyrimidine dehydrogenase & orotate phosphoribosyltransferase differed according to cancer type PMID: 19020767
25. Immunohistochemical staining for Orotate phosphoribosyl transferase (OPRT)revealed strong expression of OPRT in prostate cancer cells. There was a significant correlation between OPRT mRNA expression levels and the tumor pathological grade PMID: 19082440
26. High orotate phosphoribosyltransferase gene expression is associated with complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus PMID: 19307741
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相關疾病：

Orotic aciduria 1 (ORAC1)
蛋白家族：

Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family
數據庫鏈接：

HGNC: 12563

OMIM: 258900

KEGG: hsa:7372

STRING: 9606.ENSP00000232607

UniGene: Hs.2057

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