UMPS Antibody, HRP conjugated
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中文名稱：UMPS兔多克隆抗體, HRP偶聯
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貨號：CSB-PA728898LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) UMPS Polyclonal antibody
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Uniprot No.：
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基因名：UMPS
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別名：ODC antibody; OMPdecase antibody; OPRT antibody; OPRTase antibody; Orotate phosphoribosyl transferase and orotidine 5' decarboxylase antibody; Orotate phosphoribosyltransferase antibody; Orotate phosphoribosyltransferase phosphoribosyltransferase antibody; Orotidine 5' phosphate decarboxylase antibody; Orotidine 5''-phosphate decarboxylase antibody; RP11-71H17.9 antibody; UMP synthase antibody; Umps antibody; UMPS_HUMAN antibody; Uridine 5' monophosphate synthase antibody; Uridine monophosphate synthetase antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Uridine 5'-monophosphate synthase protein (314-444AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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基因功能參考文獻：
- Partial UMPS-deficiency should be included in the differential diagnosis of mild orotic aciduria. PMID: 28205048
- The UMPS 638 CC genotype might be a candidate biomarker predicting toxicity in patients receiving tegafur-uracil/leucovorin-based preoperative chemoradiation for locally advanced rectal cancer PMID: 28347333
- OPRT transition state analogues identify crucial components of potent inhibitors targeting OPRT enzymes. PMID: 24158442
- The observed mutations, aberrant splicing and downregulation of UMPS represent novel mechanisms for acquired 5-FU resistance in colorectal cancer PMID: 22249354
- [review] It is confirmed that the type I defect in hereditary orotic aciduria is caused by loss of uridine monophosphate (UMP)synthase activity PMID: 19562503
- OPRT expression in colorectal carcinoma tissues is not correlated with the toxicity of 5-FU, but OPRT expression in the normal tissues can help predict the toxicity associated with 5-FU. PMID: 22931617
- Although no association was detected between UMPS variants and gastrointestinal cancer risk in Caucasians, polymerase chain reaction-RFLP with BsrI digestion and DHPLC set up at 59 degrees C are reliable and cost-effective methods to genotype UMPS. PMID: 21631301
- novel phosphoribosyltransferase transition states PMID: 20527751
- orotate phosphoribosyl transferase/DPD ratio has a relation to cancer staging and survival rate. PMID: 20647710
- Increased orotate phosphoribosyltransferase expression is associated with bladder cancers. PMID: 20112501
- expression of OPRT gene and the OPRT/dihydropyrimidine dehydrogenase ratio might be useful as predictive parameters for the efficacy of fluoropyrimidine-based chemotherapy for metastatic colorectal cancer PMID: 14562021
- thymidylate synthase and orotate phosphoribosyl transferase, but not dihydropyrimidine dehydrogenase, are more highly expressed in prostate cancer than in benign prostatic hyperplasia PMID: 15999119
- orotate phosphoribosyl transferase has a role in lymph node metastasis of gastric cancer PMID: 16142362
- The investigated SNPs of OPRT may have no major influence on 5-FU sensitivity. PMID: 16328050
- The OPRT Gly213Ala polymorphism seems to be a useful marker for predicting toxicity to bolus 5-FU chemotherapy. PMID: 16818689
- Overexpression of the OPRT gene plays an important role in the antiproliferative effect of 5-FU. PMID: 17237621
- High expression of OPRT is associated with the response to adjuvant chemotherapy in human pancreatic cancer PMID: 17549346
- data suggest that OPRT is involved in early events of pancreatic and gallbladder carcinogenesis and invasion of hepatocellular carcinomas PMID: 17607371
- decreased the sensitivities of the cultured tumor cells to 5-FU. These results suggest that the OPRT expression level in tumors is an additional determinant of the efficacy of 5-FU. PMID: 17854773
- OPRT activity levels in tumor tissue may be prognostic factor for survival in colorectal carcinoma with radical resection and 5-FU chemotherapy;postoperative survival was significantly better in patients with high OPRT activity PMID: 18597678
- determination of OPRT levels in gastric carcinoma tissue enables to predict the response to S-1-based neoadjuvant/adjuvant chemotherapy PMID: 18633253
- orotate phosphoribosyltransferase is involved in the invasion and metastasis of colorectal carcinoma PMID: 18949394
- decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-FU PMID: 19020740
- head & neck, gastric, colorectal, breast, lung & pancreatic cancer were examined; findings show mRNA expression & protein level of thymidylate synthase, dihydropyrimidine dehydrogenase & orotate phosphoribosyltransferase differed according to cancer type PMID: 19020767
- Immunohistochemical staining for Orotate phosphoribosyl transferase (OPRT)revealed strong expression of OPRT in prostate cancer cells. There was a significant correlation between OPRT mRNA expression levels and the tumor pathological grade PMID: 19082440
- High orotate phosphoribosyltransferase gene expression is associated with complete response to chemoradiotherapy in patients with squamous cell carcinoma of the esophagus PMID: 19307741
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相關疾病：Orotic aciduria 1 (ORAC1)
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蛋白家族：Purine/pyrimidine phosphoribosyltransferase family; OMP decarboxylase family
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