TRIM39 Antibody
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中文名稱：TRIM39兔多克隆抗體
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貨號：CSB-PA024476GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TRIM39
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別名：HGNC:10065 antibody; MGC32984 antibody; RING finger protein 23 antibody; RNF23 antibody; Testis abundant finger protein antibody; Testis-abundant finger protein antibody; TFP antibody; TFP RING FINGER PROTEIN 23 antibody; TRI39_HUMAN antibody; Trim39 antibody; TRIM39B antibody; Tripartite motif containing 39 antibody; Tripartite motif-containing protein 39 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human TRIM39
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.; Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner.
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基因功能參考文獻(xiàn)：
- TRIM39 negatively regulates the NFkappaB signaling pathway possibly via stabilization of cactin. PMID: 26363554
- TRIM39R, but not TRIM39B, regulates type I interferon response PMID: 23707810
- TRIM39 has a role in regulating cell cycle progression and the balance between cytostasis and apoptosis after DNA damage via stabilizing p21 PMID: 23213251
- analysis of ubiquitylation of p53 by the APC/C inhibitor Trim39 PMID: 23213260
- these findings suggest that RNF39 and TRIM39 are involved in the etiology of Behcet's disease. PMID: 20875797
- Data suggest that TRIM39 can promote apoptosis signalling through stabilization of MOAP-1. PMID: 19100260
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亞細(xì)胞定位：[Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus.; [Isoform 2]: Nucleus.
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蛋白家族：TRIM/RBCC family
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組織特異性：Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.
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數(shù)據(jù)庫鏈接：
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