TNIP2 Antibody
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中文名稱：TNIP2兔多克隆抗體
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貨號：CSB-PA713993
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規格：￥1090
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圖片：
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Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-cervical-cancer, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200 -
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
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其他：
產品詳情
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Uniprot No.：
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基因名：TNIP2
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別名：A20 binding inhibitor of NF kappaB activation 2 antibody; A20-binding inhibitor of NF-kappa-B activation 2 antibody; ABIN 2 antibody; ABIN-2 antibody; Fetal liver LKB1-interacting protein antibody; FLIP1 antibody; KLIP antibody; LKB1 interacting protein antibody; TNFAIP3 interacting protein 2 antibody; TNFAIP3-interacting protein 2 antibody; TNIP2 antibody; TNIP2_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide from Human protein at AA range: 61-110
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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純化方式：The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：IHC,ELISA
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推薦稀釋比：
Application Recommended Dilution IHC IHC-p:1:50-300 ELISA 1:10000-20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
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基因功能參考文獻：
- RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
- Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
- Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
- miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
- ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
- A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
- transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
- FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
- Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
- ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
- ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
- optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
- ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
- Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
- Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
- role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
- This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428
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亞細胞定位：Cytoplasm. Nucleus.
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組織特異性：Ubiquitously expressed in all tissues examined.
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數據庫鏈接：
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