TNIP2 Antibody

說明書

中文名稱：

TNIP2兔多克隆抗體
貨號：

CSB-PA024000GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8NFZ5
基因名：

TNIP2
別名：

A20 binding inhibitor of NF kappaB activation 2 antibody; A20-binding inhibitor of NF-kappa-B activation 2 antibody; ABIN 2 antibody; ABIN-2 antibody; Fetal liver LKB1-interacting protein antibody; FLIP1 antibody; KLIP antibody; LKB1 interacting protein antibody; TNFAIP3 interacting protein 2 antibody; TNFAIP3-interacting protein 2 antibody; TNIP2 antibody; TNIP2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TNIP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.
基因功能參考文獻：
1. RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein. PMID: 29084252
2. Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20. PMID: 27916521
3. Findings suggest an expanded role for the NF-kappaB network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I, together with many RNA processing proteins and a distinct set of mRNAs. PMID: 27609421
4. miR-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma. PMID: 27044843
5. ABIN-2 acts as a positive regulator of NF-kappaB-dependent transcription by activating IKKalpha. PMID: 21784860
6. A20, ABIN-1/2, and CARD11 mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma PMID: 21266526
7. transcription repressed by promyelocytic leukemia protein expression PMID: 12080044
8. FLIP1 has a role in the regulation of NF-kappaB activity related to the role of LKB1 in tumor suppression PMID: 12595760
9. Endothelial tyrosine kinase Tie2 interacts with ABIN-2. PMID: 12609966
10. ABIN-2 exerts unexpected function in mediating transcriptional coactivation. PMID: 12753905
11. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis. PMID: 12933576
12. optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105 PMID: 15169888
13. ABIN-2 may function as a negative regulator that downregulates NF-kappaB activation during liver regeneration PMID: 16480954
14. Thus, CIH-mediated NF-kappaB activation may be a molecular mechanism linking OSA and cardiovascular pathologies seen in OSA patients. PMID: 16554025
15. Thus the present results showed a correlation between NF-kappaB activation and the repair of sublethal damage in split-dose irradiation. PMID: 17038805
16. role for an ABIN-sensitive non-classical NF-kappaB signalling pathway in the proliferation of EGFR-overexpressing tumour cells. PMID: 18622428
17. This review defines ABIN-2 based on three different parameters: ability to bind A20; ability to inhibit NF-kappaB activation upon overexpression; the presence of specific short amino acid regions of strong homology, designated ABIN homology domains. PMID: 19464428
顯示更多

收起更多
亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Ubiquitously expressed in all tissues examined.
數據庫鏈接：

HGNC: 19118

OMIM: 610669

KEGG: hsa:79155

STRING: 9606.ENSP00000321203

UniGene: Hs.368551

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human