TEX11 Antibody

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說明書

產品詳情

Uniprot No.：

Q8IYF3
基因名：

TEX11
別名：

TEX11 antibody; Testis-expressed protein 11 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Human TEX11
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
基因功能參考文獻：
1. Through the translational regulation of novel RNA targets SMC1B and TEX11, DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility. PMID: 28364521
2. Genetic screening of a large cohort of idiopathic infertile men reveals that TEX11 mutations, including frameshift and splicing acceptor site mutations, cause infertility in 1% of azoospermic men. PMID: 26136358
3. TEX11 mutations, including frameshift and splicing acceptor site mutations, cause infertility in 1% of non-obstructive azoospermic men. PMID: 26136358
4. hemizygous TEX11 mutations were a common cause of meiotic arrest and azoospermia in infertile men PMID: 25970010
5. TEX11 was specifically expressed in human testis. PMID: 11279525
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相關疾病：

Spermatogenic failure, X-linked, 2 (SPGFX2)
亞細胞定位：

Chromosome.
蛋白家族：

SPO22 family
組織特異性：

Testis-specific. Not expressed in adult ovaries.
數據庫鏈接：

HGNC: 11733

OMIM: 300311

KEGG: hsa:56159

STRING: 9606.ENSP00000340995

UniGene: Hs.121776

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