SYNM Antibody, Biotin conjugated
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中文名稱：SYNM兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA023019LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SYNM Polyclonal antibody
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Uniprot No.：
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基因名：SYNM
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別名：Desmuslin antibody; DMN antibody; KIAA0353 antibody; SYN antibody; SYNEM_HUMAN antibody; Synemin alpha antibody; Synemin antibody; Synemin beta antibody; Synemin; intermediate filament protein antibody; SYNM antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Synemin protein (1147-1417AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
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基因功能參考文獻：
- LMOD1, SYNPO2, PDLIM7, PLN, and SYNM down-regulation reflect the altered phenotype of smooth muscle cells in vascular disease and could be early sensitive markers of SMC dedifferentiation. PMID: 27470516
- alpha-Synemin localizes to the M-band of the sarcomere through interaction with the M10 region of titin PMID: 25447537
- Immunohistochemistry of synemin in reactive astrocytes and Rosenthal fibers in two patients with Alexander disease. There was an abundance of GFAP-positive Rosenthal fibers and widespread reactive gliosis in the white matter and subpial regions. PMID: 23594359
- synemin positively regulates glioblastoma cell proliferation by helping sequester PP2A away from Akt, thereby favoring Akt activation. PMID: 22337773
- Synemin knock-down did not influence the cytoskeleton expression and organization of human Chang liver cells PMID: 21144834
- SYNM could represent a novel putative breast tumor suppressor gene that is prone to epigenetic silencing. SYNM promoter methylation may become a useful predictive biomarker to stratify breast cancer patients' risk for tumor relapse. PMID: 20543860
- Desmuslin expression is required for the maintenance of vascular smooth muscle phenotype. Decreased desmuslin expression may affect differentiation of VSMCs and ultimately contribute to the development of varicose veins. PMID: 20573469
- The differences in human syncoilin and beta-synemin mRNA ratios between Duchenne muscular dystrophy and normal muscles were not statistically significant PMID: 20199207
- The LIM domain protein zyxin was identified as an interaction partner for human synemin. PMID: 19853601
- Genomic organization and single-nucleotide polymorphism map of desmuslin, a novel intermediate filament protein on chromosome 15q26.3. PMID: 11454237
- Expression of the intermediate filament protein synemin in myofibrillar myopathies and other muscle diseases. PMID: 12669240
- the default of KIAA0353 gene may play a role in the occurrence and development of varicose great saphenous vein in PDVI patients. PMID: 12887813
- The colocalization of Synemin [syn] with vimentin, GFAP, or neurofilament supports the idea that Syn is a key cross-linking protein in morphogenesis that connects different cytoskeletal structures PMID: 14552890
- Based on its localization and its expression pattern, beta-synemin functions as a structural protein involved in maintaining muscle integrity through its interactions with alpha-dystrobrevin, desmin, and other structural proteins. PMID: 15318345
- synemin is associated with ruffled membranes in addition to being distributed along the intermediate filament network PMID: 15657940
- Desmuslin is down-regulated in incompetent saphenous veins. PMID: 16476617
- Mammalian synemin is also shown to colocalize with dystrophin within muscle cell cultures PMID: 16777071
- The stability of DMN was analyzed under the action of low-level laser therapy. PMID: 17564317
- alpha-synemin, but not beta-synemin, interacts with both vinculin and metavinculin PMID: 18028034
- results revealed that synemin was modulated nearly in all human human hepatocellular carcinoma cases PMID: 18084875
- Results suggest human alpha-synemin plays an essential role in linking the heteropolymeric intermediate filament to adherens-type junctions, such as the costameres within mammalian striated muscle cells, via its interaction with talin. PMID: 18342854
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亞細胞定位：Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
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蛋白家族：Intermediate filament family
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組織特異性：Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is pre
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