SLC17A1 Antibody

說明書

中文名稱：

SLC17A1兔多克隆抗體
貨號：

CSB-PA021417GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q14916
基因名：

SLC17A1
別名：

Na(+)/PI cotransporter 1 antibody; Na/Pi-4 antibody; NAP 1 antibody; Napi1 antibody; NPT 1 antibody; Npt1 antibody; NPT1_HUMAN antibody; Renal Na(+)-dependent phosphate cotransporter 1 antibody; Renal sodium-dependent phosphate transport protein 1 antibody; Renal sodium-phosphate transport protein 1 antibody; Slc17a1 antibody; Sodium phosphate transporter antibody; Sodium-dependent phosphate transport protein 1 antibody; Sodium/phosphate cotransporter 1 antibody; Sodium/phosphate type I cotransporter antibody; Solute carrier family 17 (organic anion transporter) member 1 antibody; solute carrier family 17 (sodium phosphate), member 1 antibody; Solute carrier family 17 (vesicular glutamate transporter) member 1 antibody; Solute carrier family 17 member 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SLC17A1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Plays a role in urate transport in the kidney.
基因功能參考文獻：
1. A meta-analysis of all gout with Japanese, Caucasian and NZ Polynesian populations revealed that rs2285340 of SLC22A12 and rs1165196 of SLC17A1 showed a significant association but did not reach a genome-wide significance level. PMID: 27899376
2. I269T, a common missense variant of NPT1, might have faster conformation changes than NPT1 wild type in terms of the alternating-access model of transporters, and increases renal urate export in humans. PMID: 27906618
3. Data suggest that single nucleotide polymorphisms (SNPs) of solute carrier family 17 member 1 (SLC17A1) are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men. PMID: 26524967
4. Data suggest that single nucleotide polymorphisms (SNPs) rs9467596 and rs2096386 of the solute carrier family 17 (sodium phosphate), member 1 protein (SLC17A1) gene may have a correlation between hyperuricemia and alcohol drinking among Uygur patients. PMID: 26663070
5. Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males. PMID: 26290326
6. NPT1/SLC17A1 is a renal urate exporter in humans and its common gain-of-function variant decreases the risk of renal underexcretion gout. PMID: 25252215
7. NPT1 is responsible for urate excretion under physiological conditions and its impairment is linked with the occurrence of gout. [review] PMID: 23876149
8. We observed a clear effect of SLC17A1 genotype on fructose load in Europeans but not Polynesian subgroups. PMID: 23852697
9. Renal urate transporter SLC17A1 is the third locus associated with gout at a genome-wide level of significance. PMID: 22541845
10. results strongly suggested that NPT1 is a Cl(-)-dependent polyspecific anion exporter involved in urate excretion under physiological conditions PMID: 20566650
11. data suggest that SLC17A1 polymorphisms are associated with the development of gout. PMID: 19556210
12. structure and promoter activity, molecular cloning PMID: 11704559
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亞細胞定位：

Apical cell membrane; Multi-pass membrane protein.
蛋白家族：

Major facilitator superfamily, Sodium/anion cotransporter family
組織特異性：

Expressed in kidney cortex, liver and brain but not in other tissues.
數據庫鏈接：

HGNC: 10929

OMIM: 182308

KEGG: hsa:6568

STRING: 9606.ENSP00000244527

UniGene: Hs.205816

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