SF1 (Ab-82) Antibody
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中文名稱：SF1 (Ab-82)兔多克隆抗體
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貨號：CSB-PA963117
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規(guī)格：￥2024
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圖片：
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Western blot analysis of extracts from COLO205 cells, using SF1 (Ab-82) antibody. -
Immunohistochemistry analysis of paraffin-embedded human brain tissue using SF1 (Ab-82) antibody. -
Immunofluorescence analysis of HeLa cells, using SF1 (Ab-82) antibody.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SF1 Polyclonal antibody
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Uniprot No.：
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基因名：SF1
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized non-phosphopeptide derived from Human SF1 around the phosphorylation site of serine 82 (S-P-S(p)-P-E).
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC,IF
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:3000 IHC 1:50-1:100 IF 1:100-1:500 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
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基因功能參考文獻：
- SF1 Phosphorylation Enhances Specific Binding to U2AF(65) and Reduces Binding to 3'-Splice-Site RNA PMID: 28002734
- A novel function of SF1 in the initial recruitment of the U2 snRNP through direct interactions with two U2 snRNP-associated proteins. PMID: 26420826
- Data suggest that post-translational processing of SF1 (phosphorylation of Ser20) down-regulates nuclear import of SF1 via alterations in kinetic interaction of SF1 nuclear localization signal (NLS) with NLS receptor isoforms. PMID: 25043850
- We demonstrated that PRPF40B interacts directly with SF1 and associates with U2AF(65 PMID: 25605964
- Gomafu indirectly modulates the function of the splicing factors SF1 and Celf3 by sequestering these proteins into separate nuclear bodies. PMID: 25145264
- The conserved SPSP motif phosphorylation and the SF1/U2AF interface are essential in vivo. PMID: 23273425
- Findings suggest that Zinc finger motif-1 (ZFM1) is an important factor for the stabilization of a contractile SMC phenotype under basal or mildly activating conditions. PMID: 22906951
- central ;mystery' domain of SF1 crystals belonged to space group C2 and have most probable solvent contents of 64, 52 or 39% with three, four or five molecules per asymmetric unit, respectively PMID: 21505248
- SF1 silencing affected alternative splicing of endogenous transcripts, establishing a previously unexpected role for SF1 and branch site-like sequences in splice site selection. PMID: 21062807
- the conformational changes that are induced by assembly of the SF1/U2AF(65)/RNA complex serve to position the pre-mRNA splice site optimally for subsequent stages of splicing. PMID: 21146534
- SF3a60, 66, and 120, but not SF1, are essential for pre-mRNA splicing PMID: 15647371
- SF1 was essential for the induction of alternative mRNA splicing by the beta-catenin/TCF4 complex. PMID: 17383426
- Puf60-UHM binds to ULM sequences in the splicing factors SF1, U2AF65, and SF3b155. PMID: 18974054
- The KH-QUA2 region of SF1 defines an enlarged KH (hn RNP K) fold which is necessary and sufficient for intron branched point sequence (BPS) binding. PMID: 11691992
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亞細胞定位：Nucleus.
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蛋白家族：BBP/SF1 family
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組織特異性：Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.
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數(shù)據(jù)庫鏈接：
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