SERPINA3 Antibody

說明書

中文名稱：

SERPINA3兔多克隆抗體
貨號：

CSB-PA808693
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA808693(SERPINA3 Antibody) at dilution 1/12, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA808693(SERPINA3 Antibody) at dilution 1/12, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane: HepG2 cells, Primary antibody: CSB-PA808693(SERPINA3 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P01011
基因名：

SERPINA3
別名：

SERPINA3 antibody; AACT antibody; AACT_HUMAN antibody; ACT antibody; alpha 1 Antichymotrypsin antibody; Alpha-1-antichymotrypsin His-Pro-less antibody; Antichymotrypsin antibody; Cell growth inhibiting gene 24/25 protein antibody; Cell growth-inhibiting gene 24/25 protein antibody; GIG24 antibody; GIG25 antibody; Growth inhibiting protein 24 antibody; Growth inhibiting protein 25 antibody; MGC88254 antibody; Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase; antitrypsin) member 3 antibody; Serine (or cysteine) proteinase inhibitor clade A member 3 antibody; Serine proteinase inhibitor clade A member 3 antibody; Serpin A3 antibody; Serpin family A member 3 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3 antibody; SERPINA3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human SERPINA3
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
基因功能參考文獻：
1. SERPINA3 silencing inhibits the migration, invasion, and liver metastasis of colon cancer cells. PMID: 29855767
2. evaluation of serum proteins reveals that SERPINA1, SERPINA3 and SERPINC1 could be useful to discriminate healthy from colorectal carcinoma patients with a high sensitivity and specificity PMID: 27492143
3. This study confirms the prognostic potential of SERPINA3 expression in human cutaneous melanoma PMID: 27213583
4. AACT is downregulated in NSCLC. The GlcNAcylated AACT can effectively differentiate Stage I non-small cell lung cancer from healthy or benign lung disease samples. PMID: 26908325
5. The ACT gene (also named SERPINA3) was mapped on chromosome 14q32.1 We studied the association between Alpha-1 antichymotrypsin (ACT) signal peptide A/T polymorphism polymorphism and risk of primary intracerebral hemorrhage PMID: 26210716
6. Proteome demonstration of alpha-1-acid glycoprotein and alpha-1-antichymotrypsin candidate biomarkers for diagnosis of enterovirus 71 infection PMID: 25170552
7. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. PMID: 24817931
8. ACT-17 variation presents a risk factor for Alzheimer's disease in the worldwide population, especially in the Caucasian population. PMID: 22272609
9. This study demonistrated that SERPINA3 is changed in the dorsolateral prefrontal cortex of individuals with schizophrenia PMID: 22869038
10. Prostate specific antigen (PSA) forms complexes with alpha1-antichymotrypsin (ACT) within the prostate, which may explain, at least partially, why the ratio of serum PSA-ACT to total PSA is increased in prostate cancer. PMID: 22806587
11. the promoter of SERPINA3 is transcriptionally activated by three transcription factors (SP1, MZF1 and ZBTB7B) PMID: 22246292
12. The common alpha1-antichymotrypsin signal peptide -15A/T polymorphism may not be a major risk factor for Alzheimer disease (AD) but the polymorphism is capable of increasing late onset AD risk. [Meta-analysis] PMID: 22294107
13. Pivotal role for alpha1-antichymotrypsin in skin repair PMID: 21693707
14. alpha-1 antichymotrypsin C-terminal fragment and Apo A1 provide a plasma molecular profile, and this is associated with acute cellular renal allograft rejection. PMID: 21730889
15. human plasma serine protease inhibitor alpha(1)-antichymotrypsin inhibits staphopain C PMID: 21296644
16. The Alpha 1 antichymotrypsin is an independent histological prognostic marker for patients with Melanoma, especially those with Stage III melanoma. PMID: 20444200
17. Found a marked and persistent coronary artery bypass grafting (CABG) postoperative increase in the levels of the serpin-protease inhibitor alpha(1)-antichymotrypsin that fully maintains the inhibitory activity blunting its protease substrate cathepsin G. PMID: 20302328
18. The study concluded that the effect of the variations in the alpha-1-antichymotrypsin regulatory region must be very limited. PMID: 20378355
19. The ANTICHYMOTRYPSIN genotype and allele frequency are not different in Indian cerebral hemorrhage and cerebral ischemia compared to controls. PMID: 19959196
20. No cirrhosis secondary to ACT deficiency has been reported in children. PMID: 20158662
21. AAT efficiently inhibits both heat- and chemical-induced aggregation of various test proteins. PMID: 20117085
22. The rs4934 polymorphism of SERPINA3 is not associated with sporadic intracranial aneurysms among individuals of Chinese Han ethnicity. PMID: 19907165
23. alpha(1)-antichymotrypsin polymorphism: a risk factor for hemorrhagic stroke in normotensive subjects. PMID: 11692021
24. A25G and G39A substitutions in the AACT gene are probably one of the risk factors to Alzheimer's disease (AD) in Han Chinese. PMID: 11798857
25. no association seen between alpha 1-antichymotrypsin and time to psychosis in Alzheimer's disease PMID: 11936240
26. significantly higher in plasma of Alzheimer patients compared to controls PMID: 11959399
27. data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic Parkinson disease in our samples, whereas the ACT gene signal peptide polymorphism might not PMID: 11992569
28. Gene regulation of the serine proteinase inhibitors alpha1-antitrypsin and alpha1-antichymotrypsin. PMID: 12023832
29. alpha(1)-antitrypsin and antichymotrypsin are produced by the mammary gland and are present in milk in relatively high amounts in early lactation PMID: 12324297
30. Polymeric AACT specifically seeds the polymerization of native protein by a serpin-dependent process that occurs under physiological conditions and may be important in the deposition of AACT in plaques in patients with Alzheimer's disease. PMID: 12600202
31. overexpression of ACT by astrocytes could thus contribute to increased beta-amyloid fibril formation in Alzheimer's disease PMID: 15530656
32. Alpha1-antichymotrypsin-AA may confer a modest protection against developing early-onset Parkinson disease in women PMID: 15542006
33. Multivariate analysis showed that ACT mRNA level, but not STC2 mRNA level, in HR-positive patients, was a significant prognostic factor (P = 0.042), which was independent of tumor size and lymph node metastases. PMID: 15546506
34. The ACT TT promoter genotype was associated with an increased risk of EOAD independently from the presence of the apolipoprotein E (APOE) epsilon 4 allele. PMID: 15653173
35. serpin/furin complex stability depends on pH and regulation at the deacylation step PMID: 15659365
36. the A/T polymorphism of SERPINA3 gene is associated with the risk factor for aneurysmal subarachnoid hemorrhage PMID: 15718509
37. The onset of MSA was significantly earlier and the disease progressed significantly faster in patients with ACT-AA genotype than in those with non-ACT-AA genotypes. The ACT concentration in cerebrospinal fluid was increased in patients with ACT-AA. PMID: 15907346
38. This study findings suggest that ACT polymorphism (A/T) is a risk factor for post-stroke dementia. PMID: 15935385
39. AP-1 is a key transcription factor that, in part, controls astrocyte-specific expression of genes including the ACT and GFAP genes PMID: 16303762
40. SERPINA3 polymorphism does not have a role in primary intracerebral hemorrhage in a Polish population PMID: 16424370
41. NFI-X cooperates with (activator protein 1)AP-1 by an unknown mechanism in astrocytes, which results in the expression of a subset of astrocyte-specific genes. PMID: 16565071
42. acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4 PMID: 18056971
43. We conclude that APOE is a risk gene for amnestic mild cognitive impairment and that ACT and CHRNA7 may act in these patients as modifier genes for the time of progression to Alzheimer's disease. PMID: 18078695
44. Nur77 overexpression and RNA interference-mediated Nur77 gene knockdown analysis confirmed that SerpinA3 is indeed a novel Nur77-targeted gene. PMID: 18248459
45. A correlation of PSA levels and the alpha 1 antichymotrypsin genotype in young prostate carcinoma patients was found. PMID: 18383875
46. Alpha-1-antichymotrypsin is a pathophysiologic inhibitor that controls MMP-9 activation in skin tissue. PMID: 18401426
47. Our study did not show an association between alpha-1 antichymotrypsin signal peptide A/T polymorphism and primary intracerebral hemorrhage. PMID: 18408372
48. increased peripheral ACT levels in APOE 4 positive patients appear to predict an accelerated clinical progression PMID: 18991685
49. Ox-ACT promotes release of human monocyte chemoattractant protein-1 (MCP-1) and IL-8 from human lung type epithelial cells (A549) and normal human bronchial epithelial (NHBE) cells PMID: 19525388
50. Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19165527
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亞細胞定位：

Secreted.
蛋白家族：

Serpin family
組織特異性：

Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
數據庫鏈接：

HGNC: 16

OMIM: 107280

KEGG: hsa:12

STRING: 9606.ENSP00000376793

UniGene: Hs.534293

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