Ren1 Antibody

^{Rare Species}

中文名稱：

Ren1兔多克隆抗體
貨號：

CSB-PA019561LA01RA
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Rat Heart tissue, Rat Liver tissue
All lanes: Ren1 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 45 kDa
Observed band size: 45 kDa

IHC image of CSB-PA019561LA01RA diluted at 1:100 and staining in paraffin-embedded rat kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Ren1 Polyclonal antibody
Uniprot No.：

P08424
基因名：

Ren1
別名：

Ren1 antibody; Ren antibody; Renin antibody; EC 3.4.23.15 antibody; Angiotensinogenase antibody
宿主：

Rabbit
反應種屬：

Rat
免疫原：

Recombinant Rat Ren1 protein (65-264AA)
免疫原種屬：

Rattus norvegicus (Rat)

標記方式：

Non-conjugated

本頁面中的產品，Ren1 Antibody (CSB-PA019561LA01RA)，的標記方式是Non-conjugated。對于Ren1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA019561LB01RA	Ren1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA019561LC01RA	Ren1 Antibody, FITC conjugated
Biotin	CSB-PA019561LD01RA	Ren1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
基因功能參考文獻：
1. The influence of intracellular renin on the inward calcium current in isolated smooth muscle cells from SHR mesenteric arteries was investigated... intracellular renin in vascular resistance vessels from SHR due to internalization or expression, contributes to the regulation of vascular tone and control of peripheral resistance-an effect independently of Ang II. PMID: 27545826
2. An alternative promoter in intron1 of the renin gene is regulated by glucose starvation via SRF. PMID: 28715805
3. renin deficiency leads to significant dysregulation of ion transporters. PMID: 27443990
4. Renal ischemia/reperfusion injury induces renin response in the kidney. Renin production is more explicit in males than in females which, via increased angiotensin II production, might explain differences in renal vessel regulation between the two genders. PMID: 27090360
5. Isolated perfused hearts obtained from transgenic rats overexpressing cytosolic renin exhibited a 50 % reduction of infarct size after ischemia-reperfusion injury. PMID: 26256830
6. plasma level elevated in experimental colitis PMID: 26660905
7. elevated levels of circulating (pro)renin in model of pre-eclampsia PMID: 25767135
8. prorenin has distinct pro-angiogenic and pro-inflammatory effects on retinal cells PMID: 25707593
9. Report alterations in adrenal gland aldosterone/corticosterone biosynthesis in the renin knockout rat. PMID: 25394830
10. at least 4 BP loci reside within the 30-cM chromosome 13 BP quantitative trait locus that includes Renin PMID: 23460292
11. Up-regulation of renin might contribute to abnormal programming of renal growth in rats exposed to postnatal early overnutrition. PMID: 21752621
12. An association of post-natal overfeeding and high-fat diet increases plasma renin activity and adipose (pro)renin receptor expression. PMID: 21483231
13. This study examined angiogenic function and genomic structure of regions surrounding the renin gene. PMID: 21521778
14. Although plasma renin activity was suppressed in the angiotensinogen II-infused rats, renin content in the renal medulla was increased. Renin levels in the urine increased. PMID: 21865264
15. Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. PMID: 21963836
16. The transfer of chromosome 13 from BN to SS rats (to produce the SS.13BN strain) has cardiovascular effects. PMID: 22020141
17. Imidazolone deposition and renin production in peritubular capillary endothelial cells may play a role in the development of tubulointerstitial fibrosis in insulin-resistant hypertensive rats. PMID: 21484732
18. Cu/Zn SOD expression was significantly higher in cerebral arteries from Ren1-Brown Norway congenic rats vs. those from Dahl salt-sensitive rats PMID: 21331057
19. The development of the first rat knockout in the renin-angiotensin system emphasizes the role of renin in BP regulation and kidney function even in the low-renin SS rat. PMID: 21242461
20. Dahl SS renin allele plays a crucial role in endothelial dysfunction present in the cerebral circulation of the Dahl SS rat, even in the absence of elevated dietary salt intake. PMID: 20852041
21. The data demonstrate that a cytosolic renin exists in cardiomyocytes, which in contradiction to secretory renin protects from necrosis but increases apoptosis. PMID: 18671756
22. Nitric oxide synthase mRNA levels do not correlate with gene expression of renin in selected brain areas PMID: 11702851
23. Coronary dilatation reserve in experimental hypertension and chronic heart failure: effects of blockade of the renin-angiotensin system PMID: 11903302
24. cellular location of thymic renin is mainly in macrophages and epithelial cells and is greater in hypertensive rats PMID: 12242043
25. mRNA expression is related to renal dysfunction in tacrolimus-induced acute nephrotoxicity. PMID: 12469222
26. Intracranial renin alters gustatory neural responses in the nucleus of the solitary tract of rats. PMID: 12511427
27. cyclooxygenase 2 activity controls the renin-angiotensin system and contributes to elevated renin in the postnatal period PMID: 12560203
28. renin-specific antibodies demonstrate that cardiac mast cells contain renin PMID: 15342908
29. Results suggest that the nonproteolytic activation of prorenin may be a significant mechanism of diabetic nephropathy. PMID: 15489960
30. show that the intracellular domain of Notch1, transcription factor Ets-1, and homeo box D10 (HOXD10).pre B-cell leukemia transcription factor 1(PBX1b).PREP1 activate the rat renin promoter cooperatively PMID: 15792957
31. the augmentation of distal nephron renin in ANG II-infused hypertensive rats is AT1 receptor mediated PMID: 15870381
32. Angiotensin II-mediated oxidative stress promotes myocardial tissue remodeling in the transgenic (mRen2) 27 Ren2 rat. PMID: 17440033
33. Effect of the renin gene on skeletal muscle angiogenesis induced by electrical stimulation. PMID: 18198281
34. Release of mast cell renin triggers locally produced angiotensin II-induced contraction of rat bronchial rings in vitro. PMID: 18202178
35. in a rat model of diabetes, prorenin content and release from the collecting duct may be more important than the juxtaglomerular apparatus in contrast to the existing paradigm PMID: 18413493
36. Upregulation of distal tubular renin helps to explain how sustained intrarenal angiotensin II formation occurs even during juxtaglomerular renin suppression PMID: 18426992
37. augmented activation of the renin-angiotensin system may be related to enhanced sympathetic outflow observed in sedentary animals and may contribute to increased risk of cardiovascular disease in the sedentary population PMID: 18509102
38. Renin inhibition attenuates insulin resistance, oxidative stress, and pancreatic remodeling in the transgenic Ren2 rat. PMID: 18653711
39. Exon(1A-9) renin transcript (1) is translated into a functionally active intracellular protein; (2) is targeted to the cytoplasm rather than being sorted to the secretory pathways and (3) is functionally active, regulating aldosterone production. PMID: 18782187
40. Adipose tissue may control its own local renin concentration independently of plasma renin as a potential mechanism for maintaining a functional local adipose renin-angiotensin system. PMID: 19050177
41. mineralocorticoid receptor antagonism attenuates glomerular/podocyte remodeling and albuminuria, in part through reductions in redox-mediated impairment of insulin metabolic signaling in Ren2 rats PMID: 19261739
42. Ang peptide formation consequent to the increased prorenin levels prevented reduction of Ang II levels after binephrectomy and was likely to have contributed to hypertension, cardiac hypertrophy, and suppression of kidney renin levels in transgenic rats PMID: 19841286
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亞細胞定位：

Secreted. Membrane.
蛋白家族：

Peptidase A1 family
數據庫鏈接：

KEGG: rno:24715

STRING: 10116.ENSRNOP00000003951

UniGene: Rn.9831

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