RBM17 Antibody
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中文名稱：RBM17兔多克隆抗體
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貨號：CSB-PA853432ESR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA853432ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA853432ESR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RBM17 Polyclonal antibody
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Uniprot No.：
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基因名：RBM17
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別名：45 kDa-splicing factor antibody; RBM 17 antibody; Rbm17 antibody; RNA binding motif protein 17 antibody; RNA-binding motif protein 17 antibody; SPF 45 antibody; SPF45 antibody; SPF45_HUMAN antibody; Splicing factor (45 kD) antibody; Splicing factor (45kD) antibody; Splicing factor 45 antibody; Splicing factor 45 kDa antibody; Splicing factor 45kDa antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Splicing factor 45 protein (1-240AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.
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基因功能參考文獻：
- this work provides the structural and molecular basis of the interaction between RBM17 and the phosphorylated form of ATXN1. PMID: 24858692
- identify SPF45 as the first splicing factor regulated by multiple MAP kinase pathways and show effects of both SPF45 overexpression and phosphorylation PMID: 22615491
- dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65 PMID: 21835928
- overexpression of SPF45 in HeLa, a cervical carcinoma cell line, resulted in drug resistance to doxorubicin and vincristine PMID: 14578179
- The SPF45 regulates alternative splicing of the apoptosis regulatory gene CD95; 2.1-A crystal structure of SPF45-UHM in complex with a ULM peptide from SF3b155 is reported. PMID: 17589525
- Resistance to various chemotherapeutics resulting from stable transfection of RBM17 (SPF45) in A2780 ovarian carcinoma cells may be due to effects of SPF45 on transcription and splicing of ERbeta-regulated genes. PMID: 16061639
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亞細胞定位：Nucleus.
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數據庫鏈接：
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