RBFOX3 Antibody

中文名稱：

RBFOX3兔多克隆抗體
貨號：

CSB-PA407385LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA407385LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RBFOX3 Polyclonal antibody
Uniprot No.：

A6NFN3
基因名：

RBFOX3
別名：

FLJ56884 antibody; FLJ58356 antibody; Fox-1 homolog C antibody; fox1 homolog C antibody; Fox3 antibody; FOX3NeuN antibody; hexaribonucleotide binding protein 3 antibody; HRNBP3 antibody; NEUN antibody; neuronal nuclei antibody; Rbfox3 antibody; RFOX3_HUMAN antibody; RNA binding protein fox-1 homolog 3 antibody; RNA binding protein, fox 1 homolog (C. elegans) 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human RNA binding protein fox-1 homolog 3 protein (1-101AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RBFOX3 Antibody (CSB-PA407385LA01HU)，的標記方式是Non-conjugated。對于RBFOX3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA407385LB01HU	RBFOX3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA407385LC01HU	RBFOX3 Antibody, FITC conjugated
Biotin	CSB-PA407385LD01HU	RBFOX3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD).
基因功能參考文獻：
1. RBFOX3 knockdown synergized with 5-FU to inhibit the growth and invasion of HCC cells through PI3K/AKT and epithelial-mesenchymal transition (EMT) signaling, and promote apoptosis by activating the cytochrome-c/caspase signaling pathway. PMID: 29689552
2. In human lung tissue, Claudin-1 is higher in RBFOX3-positive cells than in RBFOX3-negative cells. Immunostaining and mRNA quantification revealed that protein levels, but not mRNA levels, of Claudin-1 are increased by RBFOX3. PMID: 28126724
3. SNPs (rs9900428, rs9907432 and rs7211029) in RBFOX3 associate with sleep latency. PMID: 27142678
4. this study show that TGF-beta-induced RBFOX3 inhibition plays an important role in epithelial-mesenchymal transition and lung cancer progression PMID: 27432190
5. NeuN was recently eventually identified as an epitope of Rbfox3. NeuN is highly conserved among species and is stably expressed during specific stages of development. NeuN has been considered to be a reliable marker of mature neurons, however, this role has been challenged by recent studies indicating that NeuN staining is variable and even absent during certain diseases and states. Review. PMID: 25680637
6. RNA splicing occurs in the nucleus hence, the altered localization of RbFox3 to the cytoplasm may lead to the downregulation of neuronal gene expression. PMID: 24215932
7. High NeuN levels are associated with supratentorial ependymomas. PMID: 23371454
8. NeuN immunocytochemical reaction in neurons of human substantia nigra was expressed much weaker than in the nucleus rubrum neurons located in the same sections. PMID: 23898728
9. NeuN (neuronal nuclei) is a neuron-specific nuclear protein identified by anti-NeuN antibody, and widely used as the postmitotic neuron marker. NeuN is identified as the Fox-3 gene product by mass spectrometry, immunoblotting, RNAi, and immunostaining. PMID: 19713214
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亞細胞定位：

Nucleus. Cytoplasm.
數據庫鏈接：

HGNC: 27097

OMIM: 616999

KEGG: hsa:146713

STRING: 9606.ENSP00000393262

UniGene: Hs.135229

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