RAB3A Antibody
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中文名稱：RAB3A兔多克隆抗體
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貨號(hào)：CSB-PA019194GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：Rab 3A antibody; RAB 3A member RAS oncogene family antibody; Rab3a antibody; RAB3A member RAS oncogene family antibody; RAB3A_HUMAN antibody; RAS associated protein RAB 3A antibody; RAS associated protein RAB3A antibody; Ras related protein Rab 3A antibody; Ras related protein Rab3A antibody; Ras-related protein Rab-3A antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human RAB3A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情
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功能：Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. Interacts with MADD (via uDENN domain); the GTP-bound form is preferred for interaction.
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基因功能參考文獻(xiàn)：
- Rab3A-22A blocks exocytosis at a stage downstream intra-acrosomal calcium release. PMID: 27613869
- Rab3a accelerates cell proliferation by increasing cyclin D1 expression, enhances anti-cancer drug resistance, and increases tumorigenicity and self-renewal of glioma cells. PMID: 24965146
- Data indicate that exocytic stimuli promote ADP ribosylation factor 6 (ARF6) activation, which accomplishes exocytosis by stimulating Rab3A GTP-Binding Protein. PMID: 25713146
- Five compounds which possess good inhibitory activity and may act as potential high affinity inhibitors against Rab3A active site were identified PMID: 24652202
- alpha-Synuclein membrane association is regulated by the Rab3a recycling machinery and presynaptic activity PMID: 23344955
- Rab27 and Rab3 sequentially regulate human sperm dense-core granule exocytosis. PMID: 22753498
- Myo5a and Rab3A are direct binding partners and interact on synaptic vesicles and the Myo5a/Rab3A complex is involved in transport of neuronal vesicles PMID: 21349835
- a possible role in glomerulopathies PMID: 12937130
- Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. PMID: 15005721
- Cholesterol content regulates acrosomal exocytosis by enhancing Rab3A plasma membrane association. PMID: 16099449
- In conclusion, we have found no evidence for RAB3A conferring susceptibility on mental retardation in the Han Chinese population. PMID: 16584842
- Initiates exocytosis in acrosome when prenylated and activated with guanosine triphosphate (GTP). PMID: 17625073
- Rab3GEP has a role as the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes PMID: 18559336
- Epac activates the small G proteins Rap1 and Rab3A to achieve exocytosis PMID: 19546222
- The maturation of amyloid precursor protein (APP) transport vesicles, including recruitment of conventional kinesin, requires Rab3A GTPase activity. PMID: 19923287
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亞細(xì)胞定位：Cytoplasm, cytosol. Lysosome. Cytoplasmic vesicle, secretory vesicle. Cell projection, axon. Cell membrane; Lipid-anchor; Cytoplasmic side.
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蛋白家族：Small GTPase superfamily, Rab family
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組織特異性：Specifically expressed in brain.
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數(shù)據(jù)庫鏈接：
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